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    btbd2a BTB (POZ) domain containing 2a [ Danio rerio (zebrafish) ]

    Gene ID: 565970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    btbd2aprovided by ZNC
    Official Full Name
    BTB (POZ) domain containing 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030829-3
    See related
    Ensembl:ENSDARG00000042091 AllianceGenome:ZFIN:ZDB-GENE-030829-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    btb2l; btbd2; wz8656; si:dkey-110c1.5
    Summary
    Predicted to be involved in neurogenesis. Predicted to be located in cytoplasm. Predicted to be active in P-body and cytosol. Is expressed in brain; oocyte; ovary; and telencephalon. Orthologous to human BTBD2 (BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See btbd2a in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (20159068..20166697, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (20134086..20143184, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD37 Neighboring gene eukaryotic translation elongation factor 2a, tandem duplicate 1 Neighboring gene eukaryotic translation elongation factor 2a, tandem duplicate 2 Neighboring gene high mobility group 20B Neighboring gene unc-13 homolog A (C. elegans)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and isolation of a BTB-POZ-containing gene expressed in oocytes and early embryos of the zebrafish Danio rerio. Smith TH, et al. Genome, 2006 Jul. PMID 16936789
    2. A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Iovine MK, et al. Genomics, 2002 Jun. PMID 12036288
    3. Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae. Qiu W, et al. Sci Total Environ, 2020 May 10. PMID 32036144
    4. A proteome map of the zebrafish (Danio rerio) lens reveals similarities between zebrafish and mammalian crystallin expression. Posner M, et al. Mol Vis, 2008 Apr 25. PMID 18449354, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing protein 2a
    Names
    BTB (POZ) domain containing 2
    btbd2l

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045092.1 → NP_001038557.1  BTB/POZ domain-containing protein 2a

      See identical proteins and their annotated locations for NP_001038557.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ241789
      UniProtKB/TrEMBL
      A0A8M9PRU4, Q09WH7
      Related
      ENSDARP00000080348.4, ENSDART00000085913.5
      Conserved Domains (4) summary
      smart00225
      Location:188 → 287
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:299 → 398
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:180 → 284
      BTB; BTB/POZ domain
      pfam08005
      Location:446 → 593
      PHR; PHR domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      20159068..20166697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469350.2 → XP_021325025.1  BTB/POZ domain-containing protein 2a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PRU4, A0A8M9PVB6
      Related
      ENSDARP00000156049.1, ENSDART00000188241.1
      Conserved Domains (3) summary
      smart00875
      Location:269 → 368
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:176 → 257
      BTB; BTB/POZ domain
      pfam08005
      Location:416 → 563
      PHR; PHR domain

    2. XM_068216350.1 → XP_068072451.1  BTB/POZ domain-containing protein 2a isoform X3

      UniProtKB/TrEMBL
      A0A8M9PRU4

    3. XM_021469351.2 → XP_021325026.2  BTB/POZ domain-containing protein 2a isoform X2

      UniProtKB/TrEMBL
      A0A8M9PRU4

    4. XM_021469352.2 → XP_021325027.1  BTB/POZ domain-containing protein 2a isoform X4

      UniProtKB/TrEMBL
      A0A8M9P4A9
      Conserved Domains (3) summary
      smart00875
      Location:81 → 180
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:1 → 69
      BTB; BTB/POZ domain
      pfam08005
      Location:228 → 375
      PHR; PHR domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395103.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      231399..239068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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