tlcd3ba TLC domain containing 3Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlcd3baprovided by ZNC
Official Full Name: TLC domain containing 3Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-2046
See related: Ensembl:ENSDARG00000026875 AllianceGenome:ZFIN:ZDB-GENE-030131-2046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fam57ba; fb95d07; zgc:73225; wu:fb95d07
Summary: Predicted to enable sphingosine N-acyltransferase activity. Acts upstream of or within several processes, including central nervous system development; lipid homeostasis; and startle response. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in brain; central nervous system; epiphysis; head; and neurons. Human ortholog(s) of this gene implicated in cone-rod dystrophy 22. Orthologous to human TLCD3B (TLC domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (21042516..21062786, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (20892776..20913037, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb95d07.x1 (e-PCR)
- UniSTS:203570

fc68c08.y1 (e-PCR)
- UniSTS:194242

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables sphingosine N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system projection neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lipid metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within startle response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TLC domain containing 3Ba

Names: TLC domain ceramide synthase 3Ba; family with sequence similarity 57 member Ba

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.