sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sdhaprovided by ZNC
Official Full Name: succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-874
See related: Ensembl:ENSDARG00000016721 AllianceGenome:ZFIN:ZDB-GENE-040426-874
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:56051; im:7141001
Summary: Predicted to enable electron transfer activity; flavin adenine dinucleotide binding activity; and succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to act upstream of or within electron transport chain. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including adaxial cell; alar plate midbrain region; eye; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Leigh disease; dilated cardiomyopathy 1GG; lung non-small cell carcinoma; mitochondrial complex II deficiency; and paraganglioma. Orthologous to human SDHA (succinate dehydrogenase complex flavoprotein subunit A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 19

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (7276064..7291733, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (7357139..7372808, complement)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables electron transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables succinate dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex II (succinate dehydrogenase)	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex II (succinate dehydrogenase)	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Names: flavoprotein subunit of complex II; fp; malate dehydrogenase [quinone] flavoprotein subunit

NP_957204.1

EC 1.3.5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200910.1 → NP_957204.1 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

See identical proteins and their annotated locations for NP_957204.1

Status: PROVISIONAL

Source sequence(s)

BC045885

UniProtKB/Swiss-Prot

Q1LV99, Q7ZVF3

UniProtKB/TrEMBL

B2GQ13

Related

ENSDARP00000018027.9, ENSDART00000015559.11

Conserved Domains (3) summary

PTZ00139
Location:45 → 661

PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional

pfam02910
Location:510 → 661

Succ_DH_flav_C; Fumarate reductase flavoprotein C-term

cl21454
Location:82 → 468

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins