brd4 bromodomain containing 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: brd4provided by ZNC
Official Full Name: bromodomain containing 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-267
See related: Ensembl:ENSDARG00000078904 AllianceGenome:ZFIN:ZDB-GENE-030131-267
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb18g03; wu:fb18g03
Summary: Enables chromatin binding activity and histone binding activity. Acts upstream of or within thrombocyte differentiation. Located in condensed chromosome and nucleus. Is expressed in several structures, including blastoderm; blastodisc; notochord; post-vent region; and tail bud. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (53116110..53225152)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (52861509..52968980)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A human Tau expressing zebrafish model of progressive supranuclear palsy identifies Brd4 as a regulator of microglial synaptic elimination.
Title: A human Tau expressing zebrafish model of progressive supranuclear palsy identifies Brd4 as a regulator of microglial synaptic elimination.
Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis
Title: Brd4 associates with mitotic chromosomes throughout early zebrafish embryogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fb18g03.x1 (e-PCR)
- UniSTS:203020

fi21c03.x1 (e-PCR)
- UniSTS:197018

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within thrombocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bromodomain-containing protein 4

Names: bromodomain 4

NP_001104751.2

EC 3.1.1.31

XP_068073563.1

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.