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    fzr1a fizzy/cell division cycle 20 related 1a [ Danio rerio (zebrafish) ]

    Gene ID: 393223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fzr1aprovided by ZNC
    Official Full Name
    fizzy/cell division cycle 20 related 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-712
    See related
    Ensembl:ENSDARG00000015254 AllianceGenome:ZFIN:ZDB-GENE-040426-712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fzr1; zgc:55450
    Summary
    Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to act upstream of or within cell division and positive regulation of ubiquitin protein ligase activity. Predicted to be part of anaphase-promoting complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fzr1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (20863071..20876562)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (20830986..20844477)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100005423 Neighboring gene deoxyhypusine hydroxylase/monooxygenase Neighboring gene si:ch73-196i15.3 Neighboring gene HAUS augmin-like complex, subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway. Robu ME, et al. PLoS One, 2012. PMID 23082190, Free PMC Article
    2. Gene expression analysis in zebrafish embryos: a potential approach to predict effect concentrations in the fish early life stage test. Weil M, et al. Environ Toxicol Chem, 2009 Sep. PMID 19402758
    3. Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae. Voelker D, et al. Aquat Toxicol, 2007 Mar 30. PMID 17292976
    4. The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish. Imai F, et al. Development, 2010 Oct. PMID 20724448
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55450

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin ligase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fizzy/cell division cycle 20 related 1a
    Names
    fizzy/cell division cycle 20 related 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200253.1 → NP_956547.1  fizzy/cell division cycle 20 related 1a

      See identical proteins and their annotated locations for NP_956547.1

      Status: PROVISIONAL

      Source sequence(s)
      BC048038
      UniProtKB/TrEMBL
      B2GS30, Q7ZUP9
      Related
      ENSDARP00000003004.8, ENSDART00000015891.10
      Conserved Domains (3) summary
      COG2319
      Location:143 → 492
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:195 → 473
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:234 → 271
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      20863071..20876562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394719.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      384969..387702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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