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    cdr2l cerebellar degeneration-related protein 2-like [ Danio rerio (zebrafish) ]

    Gene ID: 336227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdr2lprovided by ZNC
    Official Full Name
    cerebellar degeneration-related protein 2-likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8171
    See related
    Ensembl:ENSDARG00000026834 AllianceGenome:ZFIN:ZDB-GENE-030131-8171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj58a11; zgc:77462; wu:fj58a11
    Summary
    Is expressed in several structures, including nervous system; neural plate; otic vesicle; presumptive diencephalon; and presumptive telencephalon. Orthologous to human CDR2L (cerebellar degeneration related protein 2 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cdr2l in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (59951006..59981496, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (59659905..59690377, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene Aly/REF export factor Neighboring gene Rho GDP dissociation inhibitor (GDI) alpha Neighboring gene uncharacterized LOC137490783 Neighboring gene si:ch211-110e21.3 Neighboring gene RecQ helicase-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Ezhkova D, et al. Biol Open, 2023 Jun 15. PMID 37272628, Free PMC Article
    2. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cerebellar degeneration-related protein 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316894.1 → NP_001303823.1  cerebellar degeneration-related protein 2-like

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC065979, CR352225
      UniProtKB/Swiss-Prot
      Q6NZT2
      UniProtKB/TrEMBL
      A0A8M9P4Y6
      Related
      ENSDARP00000106075.1, ENSDART00000124038.3
      Conserved Domains (1) summary
      cl25732
      Location:13 → 279
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_205564.2 → NP_991127.2  cerebellar degeneration-related protein 2-like

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC065979, CR352225
      UniProtKB/Swiss-Prot
      Q6NZT2
      UniProtKB/TrEMBL
      A0A8M9P4Y6
      Related
      ENSDARP00000035047.6, ENSDART00000035878.7
      Conserved Domains (1) summary
      cl25732
      Location:13 → 279
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      59951006..59981496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469708.2 → XP_021325383.1  cerebellar degeneration-related protein 2-like isoform X1

      UniProtKB/Swiss-Prot
      Q6NZT2
      UniProtKB/TrEMBL
      A0A8M9P4Y6
      Conserved Domains (1) summary
      cl25732
      Location:13 → 279
      SMC_N; RecF/RecN/SMC N terminal domain

    2. XM_068215999.1 → XP_068072100.1  cerebellar degeneration-related protein 2-like isoform X1

      UniProtKB/Swiss-Prot
      Q6NZT2
      UniProtKB/TrEMBL
      A0A8M9P4Y6

    3. XM_021469707.2 → XP_021325382.1  cerebellar degeneration-related protein 2-like isoform X1

      UniProtKB/Swiss-Prot
      Q6NZT2
      UniProtKB/TrEMBL
      A0A8M9P4Y6
      Related
      ENSDARP00000105648.2, ENSDART00000128790.3
      Conserved Domains (1) summary
      cl25732
      Location:13 → 279
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZT2.2 GenPept UniProtKB/Swiss-Prot:Q6NZT2

    Gene LinkOut

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