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    fah fumarylacetoacetate hydrolase (fumarylacetoacetase) [ Danio rerio (zebrafish) ]

    Gene ID: 322372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fahprovided by ZNC
    Official Full Name
    fumarylacetoacetate hydrolase (fumarylacetoacetase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1091
    See related
    Ensembl:ENSDARG00000101762 AllianceGenome:ZFIN:ZDB-GENE-030131-1091
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb59b12; zgc:55316; wu:fb59b12
    Summary
    Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid metabolic process. Is expressed in epidermis; fin; head mesenchyme; liver; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See fah in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (10589047..10633603)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (10424673..10447782, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) Neighboring gene uncharacterized LOC137496149 Neighboring gene zinc finger, AN1-type domain 6 Neighboring gene uncharacterized LOC137496091 Neighboring gene cortexin domain containing 1 Neighboring gene aryl-hydrocarbon receptor nuclear translocator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarylacetoacetase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tyrosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fumarylacetoacetase
    NP_955895.1
    XP_021333072.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199601.1 → NP_955895.1  fumarylacetoacetase

      See identical proteins and their annotated locations for NP_955895.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044366
      UniProtKB/TrEMBL
      Q6NY55, Q803S0
      Related
      ENSDARP00000149145.1, ENSDART00000182624.1
      Conserved Domains (2) summary
      pfam01557
      Location:54 → 330
      FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family
      pfam09298
      Location:1 → 48
      FAA_hydrolase_N; Fumarylacetoacetase N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      10589047..10633603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021477397.2 → XP_021333072.2  fumarylacetoacetase isoform X1

      UniProtKB/TrEMBL
      A0A8M9PNK3
    Nucleotide Protein Strain
    Heading Accession and Version

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