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    gabpa GA binding protein transcription factor subunit alpha [ Danio rerio (zebrafish) ]

    Gene ID: 58110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gabpaprovided by ZNC
    Official Full Name
    GA binding protein transcription factor subunit alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-011010-2
    See related
    Ensembl:ENSDARG00000069289 AllianceGenome:ZFIN:ZDB-GENE-011010-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    e4tf; wu:fc12d11
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in endothelial cell and telencephalon. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gabpa in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (35014513..35025524)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (35205328..35216339)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ring-infected erythrocyte surface antigen-like Neighboring gene junctional adhesion molecule 2b Neighboring gene amyloid beta (A4) precursor protein b Neighboring gene si:dkey-192g7.3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio). Little AG, et al. BMC Biol, 2013 Mar 26. PMID 23531055, Free PMC Article
    2. The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Rajarao SJ, et al. Genome Res, 2001 Jul. PMID 11435403, Free PMC Article
    3. Transcriptomic characterization of cold acclimation in larval zebrafish. Long Y, et al. BMC Genomics, 2013 Sep 11. PMID 24024969, Free PMC Article
    4. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
    5. Toxicogenomic and phenotypic analyses of bisphenol-A early-life exposure toxicity in zebrafish. Lam SH, et al. PLoS One, 2011. PMID 22194820, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GA-binding protein alpha chain
    Names
    E4tf1-60 transcription factor
    GA binding protein transcription factor, alpha subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328412.1 → NP_001315341.1  GA-binding protein alpha chain

      Status: VALIDATED

      Source sequence(s)
      CR759841, EH458961, EH546232
      UniProtKB/TrEMBL
      A0A2R8QCN2, F6NQQ6, Q9I9E8
      Related
      ENSDARP00000091473.4, ENSDART00000100700.6
      Conserved Domains (3) summary
      cd08534
      Location:162 → 248
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:309 → 394
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40 → 118
      GABP-alpha; GA-binding protein alpha chain

    2. NM_131587.2 → NP_571662.1  GA-binding protein alpha chain

      See identical proteins and their annotated locations for NP_571662.1

      Status: VALIDATED

      Source sequence(s)
      CR759841, EH458961, EH546232
      UniProtKB/TrEMBL
      A0A2R8QCN2, F6NQQ6, Q9I9E8
      Related
      ENSDARP00000091474.3, ENSDART00000100701.5
      Conserved Domains (3) summary
      cd08534
      Location:162 → 248
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:309 → 394
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40 → 118
      GABP-alpha; GA-binding protein alpha chain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      35014513..35025524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167853.5 → XP_005167910.1  GA-binding protein alpha chain isoform X1

      See identical proteins and their annotated locations for XP_005167910.1

      UniProtKB/TrEMBL
      A0A2R8QCN2, F6NQQ6, Q9I9E8
      Related
      ENSDARP00000150776.1, ENSDART00000182404.1
      Conserved Domains (3) summary
      cd08534
      Location:162 → 248
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:309 → 394
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:40 → 118
      GABP-alpha; GA-binding protein alpha chain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394760.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      305084..316623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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