U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    vav3b vav 3 guanine nucleotide exchange factor b [ Danio rerio (zebrafish) ]

    Gene ID: 559145, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    vav3bprovided by ZNC
    Official Full Name
    vav 3 guanine nucleotide exchange factor bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-251
    See related
    Ensembl:ENSDARG00000075962 AllianceGenome:ZFIN:ZDB-GENE-070912-251
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk86g11; wu:fk86g11; si:ch211-255p13.2
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including immune response-regulating cell surface receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and small GTPase-mediated signal transduction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See vav3b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (15993389..16159487, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (16323892..16490895, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487750 Neighboring gene netrin-G1 Neighboring gene uncharacterized LOC101885853 Neighboring gene selenoprotein J Neighboring gene SH3-domain GRB2-like endophilin B1b

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    guanine nucleotide exchange factor VAV3b

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126393.1 → NP_001119865.1  guanine nucleotide exchange factor VAV3b

      Status: PROVISIONAL

      Source sequence(s)
      BX510321, CR788310, CT027695
      UniProtKB/TrEMBL
      A0A8M1NJ91, X1WEX4
      Related
      ENSDARP00000128776.1, ENSDART00000153480.3
      Conserved Domains (9) summary
      cd11978
      Location:767 → 821
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd00029
      Location:507 → 552
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:377 → 499
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:402 → 495
      PH; PH domain
      pfam00307
      Location:4 → 115
      CH; Calponin homology (CH) domain
      pfam00621
      Location:190 → 364
      RhoGEF; RhoGEF domain
      cl00642
      Location:148 → 208
      GCHY-1; Type I GTP cyclohydrolase folE2
      cl15255
      Location:649 → 751
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:581 → 640
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      15993389..16159487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480557.2 → XP_021336232.1  guanine nucleotide exchange factor VAV3b isoform X2

      UniProtKB/TrEMBL
      A0A8M9PXS0, B0S6C8
      Related
      ENSDARP00000099666.3, ENSDART00000110059.5
      Conserved Domains (7) summary
      cd11978
      Location:771 → 825
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd00029
      Location:511 → 556
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:191 → 367
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01223
      Location:381 → 503
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18 → 103
      CAMSAP_CH; CAMSAP CH domain
      cl15255
      Location:653 → 755
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:585 → 644
      SH3; Src Homology 3 domain superfamily

    2. XM_005163323.5 → XP_005163380.1  guanine nucleotide exchange factor VAV3b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BAQ7
      Conserved Domains (8) summary
      cd11978
      Location:798 → 852
      SH3_VAV3_2; C-terminal (or second) Src homology 3 domain of VAV3 protein
      cd00029
      Location:511 → 556
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:381 → 503
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:406 → 499
      PH; PH domain
      pfam00307
      Location:4 → 115
      CH; Calponin homology (CH) domain
      pfam00621
      Location:194 → 368
      RhoGEF; RhoGEF domain
      cl15255
      Location:653 → 755
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:585 → 644
      SH3; Src Homology 3 domain superfamily

    3. XM_068224313.1 → XP_068080414.1  guanine nucleotide exchange factor VAV3b isoform X3

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools