glo1 glyoxalase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glo1provided by ZNC
Official Full Name: glyoxalase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030722-9
See related: Ensembl:ENSDARG00000068978 AllianceGenome:ZFIN:ZDB-GENE-030722-9
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb554; zgc:66035; wu:fb82g09
Summary: Enables lactoylglutathione lyase activity. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and segmental plate. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (44788077..44808657, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (44651173..44671753, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lactoylglutathione lyase activity	IEA Inferred from Electronic Annotation more info
enables lactoylglutathione lyase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lactoylglutathione lyase

NP_998316.1

EC 4.4.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213151.1 → NP_998316.1 lactoylglutathione lyase

See identical proteins and their annotated locations for NP_998316.1

Status: PROVISIONAL

Source sequence(s)

BC062383

UniProtKB/TrEMBL

A0A8M1PIW1, Q6P696

Related

ENSDARP00000090756.3, ENSDART00000099984.4

Conserved Domains (1) summary

cl14632
Location:22 → 179

Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins