pbo-1 EF-hand domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: pbo-1
Official Full Name: EF-hand domain-containing protein
Primary source: WormBase:WBGene00003941
Locus tag: CELE_Y71H2AL.1
See related: AllianceGenome:WB:WBGene00003941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in protein transport. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Is expressed in intestine and neurons. Human ortholog(s) of this gene implicated in spastic ataxia. Orthologous to human CHP1 (calcineurin like EF-hand protein 1) and CHP2 (calcineurin like EF-hand protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

In this study, we have identified a new posterior body contraction calcium-binding protein, PBO-1/CHP, that regulates at least two intestinal sodium-proton exchangers in C. elegans
Title: A calcineurin homologous protein is required for sodium-proton exchange events in the C. elegans intestine.
PBO-1 is a critical regulator of ion channels that contribute to the pH of the intestine
Title: The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen.
Pbo-1 regulates the membrane localization and activity of NHX-2/-7 in C.elegans.
Title: Calcineurin homologous proteins regulate the membrane localization and activity of sodium/proton exchangers in C. elegans.

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Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_497601.1

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The following sections contain reference sequences that belong to a specific genome build. Explain