Lipf lipase F, gastric type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lipfprovided by RGD
Official Full Name: lipase F, gastric typeprovided by RGD
Primary source: RGD:708441
See related: EnsemblRapid:ENSRNOG00000019448 AllianceGenome:RGD:708441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rnlp; RNLIP
Summary: Enables malate dehydrogenase activity and triacylglycerol lipase activity. Acts upstream of or within malate metabolic process. Located in mitochondrion. Orthologous to human LIPF (lipase F, gastric type). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 33.7) and Lung (RPKM 17.4) See more
Orthologs: human all
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Genomic context

Location:: 1q52

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (240906706..240925053)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (231493498..231511845)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252284464..252302811)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lipase inhibition did not modify plasma octanoylated ghrelin concentration.
Title: Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration.
significance of lingual lipase in the perception of a fat taste by using orlistat, a potent lipase inhibitor
Title: Importance of lipolysis in oral cavity for orosensory detection of fat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables lipase activity	TAS Traceable Author Statement more info	PubMed
enables malate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within malate metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gastric triacylglycerol lipase

Names: GL; gastric lipase; lingual lipase; lipase, gastric; prelingual lipase

NP_059037.1

EC 3.1.1.3

XP_063128000.1

EC 3.1.1.3

XP_063128001.1

EC 3.1.1.3

XP_063128002.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.