Nat2 N-acetyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nat2provided by RGD
Official Full Name: N-acetyltransferase 2provided by RGD
Primary source: RGD:70492
See related: EnsemblRapid:ENSRNOG00000029977 AllianceGenome:RGD:70492
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nat2a
Summary: Enables arylamine N-acetyltransferase activity. Involved in several processes, including digestive tract development; response to hypoxia; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Biomarker of end stage renal disease. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT1 (N-acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Expression: Biased expression in Thymus (RPKM 36.2), Spleen (RPKM 31.0) and 9 other tissues See more
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Genomic context

Location:: 16p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (26974874..27005191, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (22207362..22238513, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (23960709..23991570, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High NAT2 expression is associated with mammary tumor susceptibility.
Title: Congenic rats with higher arylamine N-acetyltransferase 2 activity exhibit greater carcinogen-induced mammary tumor susceptibility independent of carcinogen metabolism.
High-altitude hypoxia decreases the activity and expression of CYP1A1 and NAT2, but increases that of CYP2D6.
Title: Effect of exposure to acute and chronic high-altitude hypoxia on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats.
Results demonstrate differential tissue-specific and developmental regulation of the rat Nat1 and Nat2 genes.
Title: Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.
In homozygous rapid, homozygous slow, and heterozygous intermediate Nat2 congenic rat lines, Nat2 activities were observed in all tested tissues and found to be Nat2-genotype-dependent.
Title: Systemic functional expression of N-acetyltransferase polymorphism in the F344 Nat2 congenic rat.
RT-PCR experiments demonstrated that the relative expression of the rNat transcripts in liver and 12 extrahepatic tissues was rNat1 > rNat2, while rNat3 transcripts were not detected.
Title: Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.
Treating Fischer 344 rapid and Wistar-Kyoto slow NAT2 acetylator rat strains with the neurotoxin 6-hydroxydopamine lead to a significantly greater reduction of striatal dopamine concentrations in the WKY slow acetylator strain
Title: Slow N-acetyltransferase 2 status leads to enhanced intrastriatal dopamine depletion in 6-hydroxydopamine-lesioned rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables N-hydroxyarylamine O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables N-hydroxyarylamine O-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables arylamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylamine N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables arylamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables arylamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in digestive tract development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arylamine N-acetyltransferase 2

Names: AT-2; N-Acetyltransferase-2 (arylamine N-acetyltransferase); N-acetyltransferase 2 (arylamine N-acetyltransferase); N-acetyltransferase type 2; N-hydroxyarylamine O-acetyltransferase; NAT-2; arylamide acetylase 2

NP_446306.1

EC 2.3.1.118

EC 2.3.1.5

XP_006253069.1

EC 2.3.1.118

EC 2.3.1.5

XP_006253070.1

EC 2.3.1.118

EC 2.3.1.5

XP_006253071.1

EC 2.3.1.118

EC 2.3.1.5

XP_063131108.1

EC 2.3.1.118

EC 2.3.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053854.1 → NP_446306.1 arylamine N-acetyltransferase 2

See identical proteins and their annotated locations for NP_446306.1

Status: PROVISIONAL

Source sequence(s)

U01348

UniProtKB/Swiss-Prot

P50298

UniProtKB/TrEMBL

Q45G59

Conserved Domains (1) summary

pfam00797
Location:20 → 280

Acetyltransf_2; N-acetyltransferase