Gnal G protein subunit alpha L [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnalprovided by RGD
Official Full Name: G protein subunit alpha Lprovided by RGD
Primary source: RGD:2715
See related: EnsemblRapid:ENSRNOG00000010440 AllianceGenome:RGD:2715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Olf; Golf; RGD1305940
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in cellular response to dopamine and regulation of long-term synaptic depression. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Used to study dystonia. Biomarker of traumatic brain injury. Human ortholog(s) of this gene implicated in dystonia 25. Orthologous to human GNAL (G protein subunit alpha L). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 143.5), Lung (RPKM 24.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (62892257..63032510)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (60622311..60762599)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (62805406..62946133)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway.
Title: Loss-of-function of GNAL dystonia gene impairs striatal dopamine receptors-mediated adenylyl cyclase/ cyclic AMP signaling pathway.
cAMP signaling pathway-related proteins, Pde10a and Gnal, may play important roles in the pathogenesis and recovery of mild traumatic brain injury.
Title: Quantitative Proteomic Study Reveals Up-Regulation of cAMP Signaling Pathway-Related Proteins in Mild Traumatic Brain Injury.
The major components of the olfactory transduction pathway in the rat choroid plexus have been determined, including odorant receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
Title: 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.
Thyroid hormone can down-regulate Goalpha gene transcription in the hippocampus and dentate gyrus during early brain development.
Title: [Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].
Golf immunoreactivity is exclusively localized to giant cell trophoblasts and spongiotrophoblast cells
Title: Expression of Golf in the rat placenta: Possible implication in olfactory receptor transduction.
golfalpha was found in both the end organs and the ganglia and could serve unique roles in the physiology of the vestibular neuroepithelium
Title: G-protein Golfalpha (GNAL) is expressed in the vestibular end organs and primary afferent neurons of Rattus norvegicus.
Sulfhydryl groups on subunits of this protein are alkylated by ethylmaleimide and regulated by guanine nucleotides
Title: Alkylation of sulfhydryl groups on Galpha(s/olf) subunits by N-ethylmaleimide: regulation by guanine nucleotides.

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General gene information

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Markers

d18rat89 (e-PCR)
- UniSTS:121349

UniSTS:237833 (e-PCR)
- UniSTS:237833

RH129239 (e-PCR)
- UniSTS:212547

RH129499 (e-PCR)
- UniSTS:212803

D18Arb5 (e-PCR), detects polymorphism
- UniSTS:226903

D18Wox11 (e-PCR)
- UniSTS:118116

BF417987 (e-PCR)
- UniSTS:249704

RH144614 (e-PCR)
- UniSTS:233859

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within activation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating dopamine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dopamine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of chemical stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of ciliary necklace	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(olf) subunit alpha

Names: Olf-alpha protein (olfactory neuron-specific G protein); adenylate cyclase-stimulating G alpha protein, olfactory type; guanine nucleotide binding protein, alpha activating activity polypeptide, olfactory type; guanine nucleotide binding protein, alpha stimulating, olfactory type; guanine nucleotide-binding protein G(olf), alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191836.2 → NP_001178765.1 guanine nucleotide-binding protein G(olf) subunit alpha

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018, S80376

UniProtKB/Swiss-Prot

P38406, Q64711

UniProtKB/TrEMBL

G3V8E8

Related

ENSRNOP00000025172.8, ENSRNOT00000025172.9

Conserved Domains (2) summary

cd00066
Location:112 → 444

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

smart00275
Location:93 → 447

G_alpha; G protein alpha subunit