Tkfc triokinase and FMN cyclase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tkfcprovided by RGD
Official Full Name: triokinase and FMN cyclaseprovided by RGD
Primary source: RGD:1311026
See related: EnsemblRapid:ENSRNOG00000020704 AllianceGenome:RGD:1311026
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dak; RGD1311026
Summary: Enables triokinase activity. Predicted to be involved in several processes, including carbohydrate phosphorylation; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate; and negative regulation of MDA-5 signaling pathway. Is active in cytosol. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 633.3), Kidney (RPKM 436.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (216664446..216677815, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (207238230..207253035, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (226642901..226657698, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_7549-7550:992008477:1 (e-PCR)
- UniSTS:231341

MARC_7549-7550:996687933:1 (e-PCR)
- UniSTS:231341

RH132503 (e-PCR)
- UniSTS:215786

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables FAD-AMP lyase (cyclizing) activity	IEA Inferred from Electronic Annotation more info
enables FAD-AMP lyase (cyclizing) activity	ISO Inferred from Sequence Orthology more info
enables glycerone kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerone kinase activity	IEA Inferred from Electronic Annotation more info
enables glycerone kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables triokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables triokinase activity	IEA Inferred from Electronic Annotation more info
enables triokinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	IEA Inferred from Electronic Annotation more info
involved_in fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate	ISO Inferred from Sequence Orthology more info
involved_in glycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MDA-5 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MDA-5 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of innate immune response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: triokinase/FMN cyclase

Names: bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing); dihydroxyacetone kinase 2 homolog

NP_001034120.1

EC 2.7.1.28

EC 2.7.1.29

EC 4.6.1.15

XP_006231118.1

EC 2.7.1.28

EC 2.7.1.29

EC 4.6.1.15

XP_006231119.3

EC 2.7.1.28

EC 2.7.1.29

EC 4.6.1.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.