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    Iglc1 immunoglobulin lambda constant 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100361706, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iglc1provided by RGD
    Official Full Name
    immunoglobulin lambda constant 1provided by RGD
    Primary source
    RGD:2319568
    See related
    EnsemblRapid:ENSRNOG00000058590 AllianceGenome:RGD:2319568
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in external side of plasma membrane. Predicted to be part of B cell receptor complex. Orthologous to several human genes including IGLC2 (immunoglobulin lambda constant 2); IGLC3 (immunoglobulin lambda constant 3 (Kern-Oz+ marker)); and IGLC6 (immunoglobulin lambda constant 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 152.1), Thymus (RPKM 41.3) and 2 other tissues See more
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    Genomic context

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    See Iglc1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95452233..95454185)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (81947966..81949822)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86094822..86096399)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Ig lambda-1 chain C region-like Neighboring gene Ig lambda-2 chain C region-like Neighboring gene uncharacterized LOC134480931 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene histone cell cycle regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The immunoglobulin lambda locus in rat consists of two C lambda genes and a single V lambda gene. Steen ML, et al. Gene, 1987. PMID 3114047
    2. The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Matsuuchi L, et al. Proc Natl Acad Sci U S A, 1992 Apr 15. PMID 1373499, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of B cell receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of IgG immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Ig lambda-1 chain C region-like
    Names
    Ig lambda-2 chain C region
    lambda-chain C1-region-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      95452233..95454185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088979.2 → XP_038944907.1  Ig lambda-1 chain C region-like isoform X2

      UniProtKB/Swiss-Prot
      P20766
      UniProtKB/TrEMBL
      A0A0G2K8K8
      Conserved Domains (1) summary
      cd07699
      Location:23 → 116
      IgC1_L; Immunoglobulin light chain Constant domain; member of the C1-set of Ig superfamily (IgSF) domains

    2. XM_006248649.4 → XP_006248711.1  Ig lambda-1 chain C region-like isoform X1

      See identical proteins and their annotated locations for XP_006248711.1

      UniProtKB/Swiss-Prot
      P20766
      Related
      ENSRNOP00000112385.1, ENSRNOT00000138637.1
      Conserved Domains (1) summary
      cd07699
      Location:26 → 120
      IgC_L; Immunoglobulin Constant domain
    Nucleotide Protein Strain
    Heading Accession and Version

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