Slc13a1 solute carrier family 13 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc13a1provided by RGD
Official Full Name: solute carrier family 13 member 1provided by RGD
Primary source: RGD:61919
See related: EnsemblRapid:ENSRNOG00000008121 AllianceGenome:RGD:61919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables monoatomic anion:sodium symporter activity and sodium:sulfate symporter activity. Involved in sodium ion transport and sulfate transmembrane transport. Located in apical plasma membrane. Orthologous to human SLC13A1 (solute carrier family 13 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 873.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (53534763..53612704, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (52569179..52647126, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (51121784..51199477, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data demonstrate that NaSi-1 forms a dimeric protein which is glycosylated at N591, whose sorting to the apical membrane in renal epithelial cells is brefeldin A-sensitive and independent of lipid rafts or glycosylation.
Title: Quaternary structure and apical membrane sorting of the mammalian NaSi-1 sulfate transporter in renal cell lines.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables monoatomic anion:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables secondary active sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:sulfate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:sulfate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:sulfate symporter activity	ISO Inferred from Sequence Orthology more info
enables solute:sodium symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 13 member 1

Names: Na(+)/sulfate cotransporter; naSi-1; renal sodium/sulfate cotransporter; solute carrier family 13 (sodium/sulfate symporter), member 1; solute carrier family 13 (sodium/sulfate symporters), member 1; solute carrier family 13 (sodium/sulphate symporters), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031651.2 → NP_113839.1 solute carrier family 13 member 1

See identical proteins and their annotated locations for NP_113839.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q07782

UniProtKB/TrEMBL

A0A8I6A242, A6IE79

Related

ENSRNOP00000010788.3, ENSRNOT00000010788.6

Conserved Domains (2) summary

COG0471
Location:40 → 573

CitT; Di- and tricarboxylate transporter [Carbohydrate transport and metabolism]

cd01115
Location:38 → 567

SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...