Krt18 keratin 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt18provided by RGD
Official Full Name: keratin 18provided by RGD
Primary source: RGD:619935
See related: EnsemblRapid:ENSRNOG00000047393 AllianceGenome:RGD:619935
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Krt1-18
Summary: Predicted to enable scaffold protein binding activity. Involved in several processes, including cholangiocyte apoptotic process; hepatocyte differentiation; and response to fructose. Located in external side of plasma membrane; extracellular space; and keratin filament. Part of protein-containing complex. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in liver cirrhosis and metabolic dysfunction-associated steatohepatitis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 1060.9), Thymus (RPKM 310.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (135036168..135039844)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (133157486..133161162)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (143629455..143633131)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Keratin 18 Depletion as a Possible Mechanism for the Induction of Apoptosis and Ferroptosis in the Rat Hippocampus After Hypobaric Hypoxia.
Title: Keratin 18 Depletion as a Possible Mechanism for the Induction of Apoptosis and Ferroptosis in the Rat Hippocampus After Hypobaric Hypoxia.
Results indicate a keratins K8/K18 intermediate filament (IF) contribution to the cell stiffness-extracellular matrix (ECM) interplay through a modulation of Rho-dependent actin organization.
Title: Keratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of Rho-mediated actin cytoskeleton dynamics.
Resutls show that the appearance caspase-cleaved CK18 in plasma was found to reflect formation of the caspase-cleaved epitope in
Title: Specific demonstration of drug-induced tumour cell apoptosis in human xenografts models using a plasma biomarker.
data imply that CK8/18 overexpression, those cytokeratins complex formation associated w/ histone type 2 H2aa3 upregulation & intermediate filament reorganization may drive neoplastic transformation of GST-P positive foci during rat hepatocarcinogenesis
Title: Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA891608 (e-PCR)
- UniSTS:261315

Krt18 (e-PCR), detects polymorphism
- UniSTS:525253

RH131703 (e-PCR)
- UniSTS:214986

Krt18 (e-PCR), detects polymorphism
- UniSTS:499180

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in cholangiocyte apoptotic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal stem cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in response to fructose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
is_active_in keratin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in keratin filament	IDA Inferred from Direct Assay more info	PubMed
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: keratin, type I cytoskeletal 18

Names: CK-18; K18; cytokeratin-18; keratin 18, type I; keratin complex 1, acidic, gene 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.