Camlg calcium modulating ligand [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Camlgprovided by RGD
Official Full Name: calcium modulating ligandprovided by RGD
Primary source: RGD:69297
See related: EnsemblRapid:ENSRNOG00000021911 AllianceGenome:RGD:69297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Caml
Summary: Enables cell adhesion molecule binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human CAMLG (calcium modulating ligand). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 57.1), Brain (RPKM 56.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (8997868..9009140, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (8992697..9003576, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9523792..9534683, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAML role in the hepatocyte proliferation.TMUB1 regulates hepatocyte proliferation by interacting with CAML and further interferes with the binding of CAML to cyclophilin B.
Title: TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129023 (e-PCR)
- UniSTS:212331

AA996906 (e-PCR)
- UniSTS:248062

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in B cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in tail-anchored membrane protein insertion into ER membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GET complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GET complex	IPI Inferred from Physical Interaction more info	PubMed
part_of GET complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: guided entry of tail-anchored proteins factor CAMLG

Names: calcium signal-modulating cyclophilin ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398726.1 → NP_001385655.1 guided entry of tail-anchored proteins factor CAMLG isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

F7FMD6, Q6DGG9, Q9ERK1

Related

ENSRNOP00000033945.7, ENSRNOT00000037088.7

Conserved Domains (1) summary

pfam14963
Location:21 → 291

CAML; Calcium signal-modulating cyclophilin ligand
NM_053334.2 → NP_445786.2 guided entry of tail-anchored proteins factor CAMLG isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8L2QHI2

Conserved Domains (1) summary

pfam14963
Location:21 → 290

CAML; Calcium signal-modulating cyclophilin ligand

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

8997868..9009140 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253659.5 → XP_006253721.1 guided entry of tail-anchored proteins factor CAMLG isoform X1

UniProtKB/TrEMBL

A0A8I6AH13

Related

ENSRNOP00000092138.1, ENSRNOT00000103256.2

Conserved Domains (1) summary

pfam14963
Location:21 → 269

CAML; Calcium signal-modulating cyclophilin ligand
XM_063276772.1 → XP_063132842.1 guided entry of tail-anchored proteins factor CAMLG isoform X2

Related

ENSRNOP00000108503.1, ENSRNOT00000136160.1