Acta2 actin alpha 2, smooth muscle [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acta2provided by RGD
Official Full Name: actin alpha 2, smooth muscleprovided by RGD
Primary source: RGD:621676
See related: EnsemblRapid:ENSRNOG00000058039 AllianceGenome:RGD:621676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of hepatic stellate cell activation; and positive regulation of hepatic stellate cell contraction. Located in basement membrane and stress fiber. Biomarker of rheumatic heart disease. Human ortholog(s) of this gene implicated in Moyamoya disease and thoracic aortic aneurysm. Orthologous to human ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 1292.3), Spleen (RPKM 312.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (241159723..241172503, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (231746527..231759307, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (252537614..252550394, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ultrastructural aberrations, histological disruption and upregulation of the VEGF, CD34 and ASMA immunoexpression in the myocardium of anemic albino rats.
Title: Ultrastructural aberrations, histological disruption and upregulation of the VEGF, CD34 and ASMA immunoexpression in the myocardium of anemic albino rats.
The expression of alpha-SMA during cardiac fibroblast differentiation was regulated by demethylation of its gene sequence through the inhibition of DNMT1 expression.
Title: DNA methylation regulates α-smooth muscle actin expression during cardiac fibroblast differentiation.
miR21 regulates expression of alphaSMA and collagen I in activated rat hepatic stellate cells by directly targeting Smad7.
Title: miR‑21 promotes α‑SMA and collagen I expression in hepatic stellate cells via the Smad7 signaling pathway.
considering the steroid hormone imbalance in late life period, as well as, the role of this imbalance in prostatic lesion development and progression, the aim of the study herein was to characterize and correlate prolactin, EGFR, alpha-actin and vimentin immunoreactivity in the prostatic epithelium and stroma of elderly rats, following steroid hormone imbalance.
Title: Prolactin, EGFR, vimentin and α-actin profiles in elderly rat prostate subjected to steroid hormonal imbalance.
Data suggest that the expression of actin alpha 2 smooth muscle (alpha-SMA) plays certain roles in the neuroma-associated pain, either as a direct cause of pain or as an indirect marker of existence of local mechanical stimuli.
Title: Significance of alpha smooth muscle actin expression in traumatic painful neuromas: a pilot study in rats.
TGF-beta1 and alpha-SMA expression is reduced in a rat model of hepatic fibrosis treated with antigenic peptide vaccine
Title: A Targeted Multiple Antigenic Peptide Vaccine Augments the Immune Response to Self TGF-β1 and Suppresses Ongoing Hepatic Fibrosis.
Expressions of M2R and M3R mRNA were increased in urothelial cells and decreased in detrusor muscles following chronic cystitis.
Title: Laser-capture microdissection for analysis of cell type-specific gene expression of muscarinic receptor subtypes in the rat bladder with cyclophosphamide-induced cystitis.
Smooth muscle alpha-actin is present in the cervix of virgin, 11 day, and 20 day pregnant rats.
Title: The persistence of active smooth muscle in the female rat cervix through pregnancy.
Data suggest that the myosin-II mediated drebrin A-actin exodus might be an initial event in chemical long-term potentiation (LTP) induction, triggering actin polymerization and spine enlargement.
Title: Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines.
Acta2 is important for myofibroblast cells motility, contraction and regulation of signaling processes during wound healing.
Title: Smooth muscle α actin (Acta2) and myofibroblast function during hepatic wound healing.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Acta2 (e-PCR), detects polymorphism
- UniSTS:547633

PMC23952P1 (e-PCR)
- UniSTS:272216

GDB:624560 (e-PCR)
- UniSTS:158349

PMC305873P2 (e-PCR)
- UniSTS:272568

Acta2 (e-PCR), detects polymorphism
- UniSTS:463359

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in glomerular mesangial cell development	IEA Inferred from Electronic Annotation more info
involved_in glomerular mesangial cell development	ISO Inferred from Sequence Orthology more info
involved_in juxtaglomerular apparatus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mesenchyme migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of hepatic stellate cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatic stellate cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hepatic stellate cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IEA Inferred from Electronic Annotation more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle contraction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vascular associated smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in smooth muscle contractile fiber	IEA Inferred from Electronic Annotation more info
located_in smooth muscle contractile fiber	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: actin, aortic smooth muscle

Names: actin, alpha 2, smooth muscle, aorta; alpha-actin-2; smooth muscle alpha-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.