Cnrip1 cannabinoid receptor interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnrip1provided by RGD
Official Full Name: cannabinoid receptor interacting protein 1provided by RGD
Primary source: RGD:1308373
See related: EnsemblRapid:ENSRNOG00000005326 AllianceGenome:RGD:1308373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Crip1a; RGD1308373
Summary: Enables type 1 cannabinoid receptor binding activity. Predicted to be involved in negative regulation of signaling receptor activity and regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynapse. Orthologous to human CNRIP1 (cannabinoid receptor interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 222.3), Lung (RPKM 55.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (95664435..95707062)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (91462877..91492739)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (100217547..100247235)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CRIP1a can compete with beta-arrestins for interaction with C-terminal CB1R domains that could affect agonist-driven, beta-arrestin-mediated internalization of the CB1R.
Title: Cannabinoid Receptor Interacting Protein 1a Competition with β-Arrestin for CB1 Receptor Binding Sites.
CRIP1a appears to act as a broad negative regulator of CB1 receptor function
Title: Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation.
Increased expression of CRIP1a in corpus striatum occurs after knockdown of CB1 receptor or dopamine D2 receptor.
Title: Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems.
Gene expression levels of both cannabinoid receptor interacting protein 1 and CB1 receptor were elevated following kainic acid induced seizures.
Title: Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.
Cnrip gene product, CRIP1a, inhibits basal activity of the CB1 cannabinoid receptor (cnr1).
Title: CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.
Replication of the suppressive effects by CB1 antagonism in the nucleus accumbens and ventral tegmental area suggests that endocannabinoids and their receptors mediate ethanol reinforcement through interaction with the mesolimbic dopamine pathway.
Title: Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats.
We conclude WIN inhibits the neurotransmission in the NTS of young rats via a receptor distinct from CB1 or CB2.
Title: Inhibition of spontaneous neurotransmission in the nucleus of solitary tract of the rat by the cannabinoid agonist WIN 55212-2 is not via CB1 or CB2 receptors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables type 1 cannabinoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 cannabinoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 1 cannabinoid receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CB1 cannabinoid receptor-interacting protein 1

Names: CB1 cannabinoid receptor interacting; CRIP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.