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    Clec16a C-type lectin domain family 16, member A [ Mus musculus (house mouse) ]

    Gene ID: 74374, updated on 9-Dec-2024

    Summary

    Official Symbol
    Clec16aprovided by MGI
    Official Full Name
    C-type lectin domain family 16, member Aprovided by MGI
    Primary source
    MGI:MGI:1921624
    See related
    Ensembl:ENSMUSG00000068663 AllianceGenome:MGI:1921624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    curt; mKIAA0350; 4932416N17Rik
    Summary
    Involved in protein destabilization and regulation of proteasomal ubiquitin-dependent protein catabolic process. Acts upstream of or within negative regulation of mitophagy; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of autophagosome maturation. Located in endolysosome membrane. Is expressed in islets of Langerhans. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 3.2), cortex adult (RPKM 3.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Clec16a in Genome Data Viewer
    Location:
    16 A1; 16 5.68 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10363173..10562742)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10545309..10744878)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene class II transactivator Neighboring gene predicted gene, 57630 Neighboring gene STARR-positive B cell enhancer ABC_E5523 Neighboring gene STARR-positive B cell enhancer ABC_E10887 Neighboring gene dexamethasone-induced transcript Neighboring gene STARR-seq mESC enhancer starr_40088 Neighboring gene predicted gene, 52264 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10666979-10667180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10668626-10668834 Neighboring gene predicted gene 15558 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10690115-10690396 Neighboring gene STARR-seq mESC enhancer starr_40095 Neighboring gene predicted gene, 53935 Neighboring gene STARR-positive B cell enhancer ABC_E3162 Neighboring gene suppressor of cytokine signaling 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Clone Names

    • KIAA0350

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cytosol  
    located_in endolysosome membrane PubMed 
    colocalizes_with late endosome  
    located_in vesicle  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204229.1NP_001191158.1  protein CLEC16A isoform 2

      See identical proteins and their annotated locations for NP_001191158.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC122352, AC154430, CT010583
      Consensus CDS
      CCDS57018.1
      UniProtKB/TrEMBL
      Z4YLG3
      Related
      ENSMUSP00000123189.2, ENSMUST00000155633.8
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; uncharacterized conserved protein
    2. NM_177562.5NP_808230.2  protein CLEC16A isoform 1

      See identical proteins and their annotated locations for NP_808230.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC122352, AK122255, BU700909
      Consensus CDS
      CCDS37253.1
      UniProtKB/Swiss-Prot
      A6X932, B2RSL3, Q3TCF2, Q3U0F5, Q3U2F6, Q80U30, Q8CEQ8
      UniProtKB/TrEMBL
      Z4YLG3
      Related
      ENSMUSP00000065423.8, ENSMUST00000066345.15
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; uncharacterized conserved protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10363173..10562742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522660.3XP_006522723.1  protein CLEC16A isoform X1

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    2. XM_006522662.3XP_006522725.1  protein CLEC16A isoform X3

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    3. XM_030249311.1XP_030105171.1  protein CLEC16A isoform X4

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    4. XM_006522661.3XP_006522724.1  protein CLEC16A isoform X2

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    5. XM_006522663.3XP_006522726.1  protein CLEC16A isoform X5

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    6. XM_036160163.1XP_036016056.1  protein CLEC16A isoform X6

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    7. XM_036160164.1XP_036016057.1  protein CLEC16A isoform X7

      UniProtKB/TrEMBL
      Z4YLG3
      Related
      ENSMUSP00000111493.2, ENSMUST00000115827.8
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    8. XM_036160165.1XP_036016058.1  protein CLEC16A isoform X9

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    9. XM_017317148.2XP_017172637.1  protein CLEC16A isoform X10

      UniProtKB/TrEMBL
      H7BXB6
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    10. XM_006522665.4XP_006522728.1  protein CLEC16A isoform X12

      UniProtKB/TrEMBL
      H7BXB6
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    11. XM_036160166.1XP_036016059.1  protein CLEC16A isoform X14

      UniProtKB/TrEMBL
      H7BXB6
      Related
      ENSMUSP00000111494.3, ENSMUST00000115828.9
      Conserved Domains (2) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
      pfam12485
      Location:373432
      SLY; Lymphocyte signaling adaptor protein
    12. XM_030249313.2XP_030105173.1  protein CLEC16A isoform X16

      UniProtKB/TrEMBL
      H7BXB6
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    13. XM_030249312.2XP_030105172.1  protein CLEC16A isoform X13

      UniProtKB/TrEMBL
      H7BXB6
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    14. XM_017317149.2XP_017172638.1  protein CLEC16A isoform X15

      UniProtKB/TrEMBL
      H7BXB6
      Conserved Domains (1) summary
      pfam09758
      Location:51198
      FPL; Uncharacterized conserved protein
    15. XM_011246027.4XP_011244329.1  protein CLEC16A isoform X8

      UniProtKB/TrEMBL
      Z4YLG3
      Conserved Domains (1) summary
      pfam09758
      Location:160
      FPL; Uncharacterized conserved protein
    16. XM_006522664.4XP_006522727.1  protein CLEC16A isoform X11

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