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    Ikzf1 IKAROS family zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 22778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ikzf1provided by MGI
    Official Full Name
    IKAROS family zinc finger 1provided by MGI
    Primary source
    MGI:MGI:1342540
    See related
    Ensembl:ENSMUSG00000018654 AllianceGenome:MGI:1342540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik
    Summary
    The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in thymus adult (RPKM 67.8), spleen adult (RPKM 38.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ikzf1 in Genome Data Viewer
    Location:
    11 A1; 11 7.02 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11634970..11722930)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11684962..11772930)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2348 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11464295-11464600 Neighboring gene STARR-seq mESC enhancer starr_28596 Neighboring gene predicted gene, 29945 Neighboring gene predicted gene 11998 Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene STARR-seq mESC enhancer starr_28597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11557248-11557441 Neighboring gene predicted gene 11999 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11590032-11590333 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11611793-11612034 Neighboring gene STARR-positive B cell enhancer ABC_E5207 Neighboring gene predicted gene 12000 Neighboring gene STARR-positive B cell enhancer ABC_E3931 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11666148-11666448 Neighboring gene STARR-positive B cell enhancer ABC_E6952 Neighboring gene STARR-seq mESC enhancer starr_28598 Neighboring gene fidgetin-like 1 Neighboring gene STARR-seq mESC enhancer starr_28601 Neighboring gene STARR-seq mESC enhancer starr_28602 Neighboring gene dopa decarboxylase Neighboring gene predicted gene, 51937

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ikaros mediates gene silencing in T cells through Polycomb repressive complex 2. Oravecz A, et al. Nat Commun, 2015 Nov 9. PMID 26549758, Free PMC Article
    2. A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Dovat S, et al. Genes Dev, 2002 Dec 1. PMID 12464629, Free PMC Article
    3. Plasmacytoid dendritic cells are dispensable during primary influenza virus infection. Wolf AI, et al. J Immunol, 2009 Jan 15. PMID 19124730
    4. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros. Schjerven H, et al. Nat Immunol, 2013 Oct. PMID 24013668, Free PMC Article
    5. Cutting edge: Ikaros is a regulator of Th2 cell differentiation. Quirion MR, et al. J Immunol, 2009 Jan 15. PMID 19124715, Free PMC Article

    See all (248) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
      Title: The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene.
    2. Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
      Title: Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function.
    3. Ikaros is a principal regulator of Aire[+] mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
      Title: Ikaros is a principal regulator of Aire(+) mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
    4. Impaired tissue homing by the Ikzf3[N159S] variant is mediated by interfering with Ikaros function.
      Title: Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function.
    5. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
      Title: Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
    6. Myeloid Ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver.
      Title: Myeloid Ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver.
    7. A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.
      Title: A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.
    8. An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
      Title: An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
    9. Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.
      Title: Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.
    10. deletion of the E120 enhancer resulted in a significant reduction of Ikzf1 mRNA. However, the epigenetic landscape and 3D topology of the locus were only slightly affected, highlighting the complexity of the regulatory landscape regulating the Ikzf1 locus.
      Title: Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.
    Submit: New GeneRIF Correction See all GeneRIFs (102)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4227

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly-pyrimidine tract binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within Peyer's patch development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within amacrine cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal bipolar neuron differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within thymus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein Ikaros
    Names
    ikaros family zinc finger protein 1
    lymphoid transcription factor LyF-1
    zinc finger protein, subfamily 1A, 1 (Ikaros)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025597.3 → NP_001020768.1  DNA-binding protein Ikaros isoform 1

      See identical proteins and their annotated locations for NP_001020768.1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24436.1
      UniProtKB/TrEMBL
      G5E8H3, Q571F4
      Related
      ENSMUSP00000075992.5, ENSMUST00000076700.11
      Conserved Domains (2) summary
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001301863.2 → NP_001288792.1  DNA-binding protein Ikaros isoform 1

      See identical proteins and their annotated locations for NP_001288792.1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24436.1
      UniProtKB/TrEMBL
      G5E8H3, Q571F4
      Related
      ENSMUSP00000159473.1, ENSMUST00000240540.1
      Conserved Domains (2) summary
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001301865.2 → NP_001288794.1  DNA-binding protein Ikaros isoform 2

      See identical proteins and their annotated locations for NP_001288794.1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24437.1
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0
      Conserved Domains (2) summary
      COG5048
      Location:1 → 131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001301866.2 → NP_001288795.1  DNA-binding protein Ikaros isoform 3

      See identical proteins and their annotated locations for NP_001288795.1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q3UQ33, Q5GGW5
      Related
      ENSMUSP00000159476.1, ENSMUST00000240543.1
      Conserved Domains (4) summary
      COG5048
      Location:1 → 112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:58 → 80
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:72 → 97
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001301868.2 → NP_001288797.1  DNA-binding protein Ikaros isoform 4

      See identical proteins and their annotated locations for NP_001288797.1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (3) summary
      COG5048
      Location:143 → 481
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001404490.1 → NP_001391419.1  DNA-binding protein Ikaros isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    7. NM_001404491.1 → NP_001391420.1  DNA-binding protein Ikaros isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    8. NM_001404492.1 → NP_001391421.1  DNA-binding protein Ikaros isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4, Q5SWT9

    9. NM_001404493.1 → NP_001391422.1  DNA-binding protein Ikaros isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4, Q5SWT9
      Related
      ENSMUSP00000067372.6, ENSMUST00000065433.12

    10. NM_001404494.1 → NP_001391423.1  DNA-binding protein Ikaros isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4, Q5SWT9

    11. NM_001404495.1 → NP_001391424.1  DNA-binding protein Ikaros isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    12. NM_001404496.1 → NP_001391425.1  DNA-binding protein Ikaros isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    13. NM_001404497.1 → NP_001391426.1  DNA-binding protein Ikaros isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    14. NM_001404498.1 → NP_001391427.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    15. NM_001404499.1 → NP_001391428.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    16. NM_001404500.1 → NP_001391429.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    17. NM_001404501.1 → NP_001391430.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    18. NM_001404502.1 → NP_001391431.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    19. NM_001404503.1 → NP_001391432.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    20. NM_001404504.1 → NP_001391433.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    21. NM_001404505.1 → NP_001391434.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    22. NM_001404506.1 → NP_001391435.1  DNA-binding protein Ikaros isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      G5E8H3, Q571F4

    23. NM_001404507.1 → NP_001391436.1  DNA-binding protein Ikaros isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    24. NM_001404508.1 → NP_001391437.1  DNA-binding protein Ikaros isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    25. NM_001404509.1 → NP_001391438.1  DNA-binding protein Ikaros isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    26. NM_001404510.1 → NP_001391439.1  DNA-binding protein Ikaros isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    27. NM_001404511.1 → NP_001391440.1  DNA-binding protein Ikaros isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    28. NM_001404512.1 → NP_001391441.1  DNA-binding protein Ikaros isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    29. NM_001404513.1 → NP_001391442.1  DNA-binding protein Ikaros isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    30. NM_001404514.1 → NP_001391443.1  DNA-binding protein Ikaros isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    31. NM_001404515.1 → NP_001391444.1  DNA-binding protein Ikaros isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    32. NM_001404516.1 → NP_001391445.1  DNA-binding protein Ikaros isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    33. NM_001404517.1 → NP_001391446.1  DNA-binding protein Ikaros isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    34. NM_001404518.1 → NP_001391447.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    35. NM_001404519.1 → NP_001391448.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    36. NM_001404520.1 → NP_001391449.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    37. NM_001404521.1 → NP_001391450.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    38. NM_001404522.1 → NP_001391451.1  DNA-binding protein Ikaros isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    39. NM_001404523.1 → NP_001391452.1  DNA-binding protein Ikaros isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    40. NM_001404524.1 → NP_001391453.1  DNA-binding protein Ikaros isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    41. NM_001404525.1 → NP_001391454.1  DNA-binding protein Ikaros isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    42. NM_001404526.1 → NP_001391455.1  DNA-binding protein Ikaros isoform 33

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    43. NM_001404527.1 → NP_001391456.1  DNA-binding protein Ikaros isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    44. NM_001404531.1 → NP_001391460.1  DNA-binding protein Ikaros isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    45. NM_001404532.1 → NP_001391461.1  DNA-binding protein Ikaros isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    46. NM_001404533.1 → NP_001391462.1  DNA-binding protein Ikaros isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    47. NM_001404534.1 → NP_001391463.1  DNA-binding protein Ikaros isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    48. NM_001404535.1 → NP_001391464.1  DNA-binding protein Ikaros isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    49. NM_001404537.1 → NP_001391466.1  DNA-binding protein Ikaros isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q571F4

    50. NM_001404539.1 → NP_001391468.1  DNA-binding protein Ikaros isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    51. NM_001404540.1 → NP_001391469.1  DNA-binding protein Ikaros isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    52. NM_001404542.1 → NP_001391471.1  DNA-binding protein Ikaros isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    53. NM_001404543.1 → NP_001391472.1  DNA-binding protein Ikaros isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0

    54. NM_001404544.1 → NP_001391473.1  DNA-binding protein Ikaros isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0

    55. NM_001404545.1 → NP_001391474.1  DNA-binding protein Ikaros isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0

    56. NM_001404547.1 → NP_001391476.1  DNA-binding protein Ikaros isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0

    57. NM_001404549.1 → NP_001391478.1  DNA-binding protein Ikaros isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0

    58. NM_001404550.1 → NP_001391479.1  DNA-binding protein Ikaros isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    59. NM_001404551.1 → NP_001391480.1  DNA-binding protein Ikaros isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    60. NM_001404552.1 → NP_001391481.1  DNA-binding protein Ikaros isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051

    61. NM_001404553.1 → NP_001391482.1  DNA-binding protein Ikaros isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL596450

    62. NM_001404554.1 → NP_001391483.1  DNA-binding protein Ikaros isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL596450

    63. NM_001404555.1 → NP_001391484.1  DNA-binding protein Ikaros isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q3UQ33, Q5GGW5

    64. NM_001404556.1 → NP_001391485.1  DNA-binding protein Ikaros isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q3UQ33, Q5GGW5

    65. NM_001404557.1 → NP_001391486.1  DNA-binding protein Ikaros isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q3UQ33, Q5GGW5

    66. NM_001404558.1 → NP_001391487.1  DNA-binding protein Ikaros isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5

    67. NM_001404559.1 → NP_001391488.1  DNA-binding protein Ikaros isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5

    68. NM_001404560.1 → NP_001391489.1  DNA-binding protein Ikaros isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5

    69. NM_001404561.1 → NP_001391490.1  DNA-binding protein Ikaros isoform 27

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5

    70. NM_001404562.1 → NP_001391491.1  DNA-binding protein Ikaros isoform 28

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5

    71. NM_001404563.1 → NP_001391492.1  DNA-binding protein Ikaros isoform 34

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5
      Related
      ENSMUSP00000159477.1, ENSMUST00000240544.1

    72. NM_001404564.1 → NP_001391493.1  DNA-binding protein Ikaros isoform 29

      Status: REVIEWED

      Source sequence(s)
      AL596450

    73. NM_001404565.1 → NP_001391494.1  DNA-binding protein Ikaros isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL596450

    74. NM_001404567.1 → NP_001391496.1  DNA-binding protein Ikaros isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL596450

    75. NM_001404568.1 → NP_001391497.1  DNA-binding protein Ikaros isoform 30

      Status: REVIEWED

      Source sequence(s)
      AL596450

    76. NM_001404569.1 → NP_001391498.1  DNA-binding protein Ikaros isoform 31

      Status: REVIEWED

      Source sequence(s)
      AL596450
      UniProtKB/TrEMBL
      Q5GGW5

    77. NM_009578.4 → NP_033604.2  DNA-binding protein Ikaros isoform 2

      See identical proteins and their annotated locations for NP_033604.2

      Status: REVIEWED

      Source sequence(s)
      AL596450
      Consensus CDS
      CCDS24437.1
      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      UniProtKB/TrEMBL
      Q5SWU0
      Related
      ENSMUSP00000018798.7, ENSMUST00000018798.7
      Conserved Domains (2) summary
      COG5048
      Location:1 → 131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11634970..11722930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243705.2 → XP_011242007.1  DNA-binding protein Ikaros isoform X6

      See identical proteins and their annotated locations for XP_011242007.1

      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (3) summary
      COG5048
      Location:179 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:155 → 175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:168 → 192
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011243711.2 → XP_011242013.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242013.1

      UniProtKB/TrEMBL
      Q571F4, Q5SWT9
      Conserved Domains (3) summary
      COG5048
      Location:163 → 511
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011243701.3 → XP_011242003.1  DNA-binding protein Ikaros isoform X2

      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (3) summary
      COG5048
      Location:163 → 501
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    4. XM_011243707.3 → XP_011242009.1  DNA-binding protein Ikaros isoform X8

      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (3) summary
      COG5048
      Location:163 → 466
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011243706.3 → XP_011242008.1  DNA-binding protein Ikaros isoform X7

      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011243713.3 → XP_011242015.1  DNA-binding protein Ikaros isoform X10

      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      Conserved Domains (2) summary
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain

    7. XM_011243703.3 → XP_011242005.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011242005.1

      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (3) summary
      COG5048
      Location:143 → 481
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119 → 139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132 → 156
      zf-H2C2_2; Zinc-finger double domain

    8. XM_011243716.2 → XP_011242018.1  DNA-binding protein Ikaros isoform X14

      UniProtKB/Swiss-Prot
      Q03267, Q64044, Q64045, Q64051
      Conserved Domains (2) summary
      COG5048
      Location:1 → 131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_011243718.2 → XP_011242020.1  DNA-binding protein Ikaros isoform X17

      UniProtKB/TrEMBL
      Q5GGW5
      Conserved Domains (4) summary
      COG5048
      Location:1 → 112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:60 → 80
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:58 → 80
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:72 → 97
      zf-H2C2_2; Zinc-finger double domain

    10. XM_011243704.3 → XP_011242006.1  DNA-binding protein Ikaros isoform X6

      See identical proteins and their annotated locations for XP_011242006.1

      UniProtKB/TrEMBL
      Q571F4
      Conserved Domains (3) summary
      COG5048
      Location:179 → 527
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:155 → 175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:168 → 192
      zf-H2C2_2; Zinc-finger double domain

    11. XM_011243710.4 → XP_011242012.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242012.1

      UniProtKB/TrEMBL
      Q571F4, Q5SWT9
      Conserved Domains (3) summary
      COG5048
      Location:163 → 511
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152 → 176
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03267.2 GenPept UniProtKB/Swiss-Prot:Q03267

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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