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    Trpc5 transient receptor potential cation channel, subfamily C, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 22067, updated on 27-Nov-2024

    Summary

    Official Symbol
    Trpc5provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 5provided by MGI
    Primary source
    MGI:MGI:109524
    See related
    Ensembl:ENSMUSG00000041710 AllianceGenome:MGI:109524
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CCE2; TRP5; TRP-5; Trrp5
    Summary
    Enables inositol 1,4,5 trisphosphate binding activity. Involved in neuron apoptotic process and phosphatidylserine exposure on apoptotic cell surface. Is active in presynapse. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; immune system; and liver and biliary system. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.2), frontal lobe adult (RPKM 1.0) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trpc5 in Genome Data Viewer
    Location:
    X F2; X 65.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (143160323..143471176, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (144377327..144688180, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48041 Neighboring gene STARR-seq mESC enhancer starr_48042 Neighboring gene STARR-seq mESC enhancer starr_48044 Neighboring gene predicted gene, 33235 Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene asparagine-linked glycosylation 13 Neighboring gene transient receptor potential cation channel, subfamily C, member 5, opposite strand Neighboring gene BRCA1 associated RING domain 1 pseudogene Neighboring gene MAGE family member B16, pseudogene 1 Neighboring gene retrotransposon Gag like 4 Neighboring gene predicted gene, 41903 Neighboring gene COMM domain containing 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (12)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124500

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actinin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol 1,4,5 trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylserine exposure on apoptotic cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of membrane hyperpolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of membrane hyperpolarization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    short transient receptor potential channel 5
    Names
    capacitative calcium entry channel 2
    transient receptor protein 5
    trp-related protein 5
    vtransient receptor potential cation channel, subfamily C, member 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009428.3NP_033454.1  short transient receptor potential channel 5

      See identical proteins and their annotated locations for NP_033454.1

      Status: VALIDATED

      Source sequence(s)
      AK038531, AK047867, AL713978, AL731701
      Consensus CDS
      CCDS30457.1
      UniProtKB/Swiss-Prot
      Q61059, Q9QWT1, Q9QX29, Q9R0D4
      UniProtKB/TrEMBL
      Q2KHN9, Q8C8A8
      Related
      ENSMUSP00000049063.4, ENSMUST00000040184.4
      Conserved Domains (4) summary
      cd00204
      Location:35162
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:17756
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:176235
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:6998
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      143160323..143471176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)