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    Tpbg trophoblast glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 21983, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tpbgprovided by MGI
    Official Full Name
    trophoblast glycoproteinprovided by MGI
    Primary source
    MGI:MGI:1341264
    See related
    Ensembl:ENSMUSG00000035274 AllianceGenome:MGI:1341264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5T4; WAIF1
    Summary
    Acts upstream of or within several processes, including dendrite arborization; olfactory learning; and positive regulation of intracellular signal transduction. Located in several cellular components, including axon terminus; dendrite; and endoplasmic reticulum. Is expressed in several structures, including brain; epithelium; extraembryonic component; skin; and urinary system. Orthologous to human TPBG (trophoblast glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.0), limb E14.5 (RPKM 6.2) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Tpbg in Genome Data Viewer
    Location:
    9 E3.1; 9 46.4 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (85724433..85729110)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (85842380..85847057)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24823 Neighboring gene RIKEN cDNA 9330154J02 gene Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24825 Neighboring gene STARR-seq mESC enhancer starr_24827 Neighboring gene STARR-seq mESC enhancer starr_24828 Neighboring gene STARR-seq mESC enhancer starr_24829 Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in axon terminus PubMed 
    located_in cytoplasm PubMed 
    located_in dendrite PubMed 
    located_in endoplasmic reticulum PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    trophoblast glycoprotein
    Names
    5T4 oncofetal antigen
    5T4 oncofetal trophoblast glycoprotein
    5T4 oncotrophoblast glycoprotein
    wnt-activated inhibitory factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164792.2NP_001158264.1  trophoblast glycoprotein precursor

      See identical proteins and their annotated locations for NP_001158264.1

      Status: VALIDATED

      Source sequence(s)
      AC158516
      Consensus CDS
      CCDS23380.1
      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Related
      ENSMUSP00000096101.4, ENSMUST00000098500.5
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217276
      LRR_8; Leucine rich repeat
    2. NM_011627.5NP_035757.2  trophoblast glycoprotein precursor

      See identical proteins and their annotated locations for NP_035757.2

      Status: VALIDATED

      Source sequence(s)
      AC158516
      Consensus CDS
      CCDS23380.1
      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Related
      ENSMUSP00000006559.8, ENSMUST00000006559.14
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217276
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      85724433..85729110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313282.3XP_017168771.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217276
      LRR_8; Leucine rich repeat
    2. XM_017313281.2XP_017168770.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217276
      LRR_8; Leucine rich repeat
    3. XM_017313280.2XP_017168769.1  trophoblast glycoprotein isoform X1

      UniProtKB/Swiss-Prot
      Q3UPI2, Q6PE98, Q8BQA4, Q9Z0L0
      Conserved Domains (4) summary
      smart00013
      Location:6295
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:300351
      LRRCT; Leucine rich repeat C-terminal domain
      sd00033
      Location:7395
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:217276
      LRR_8; Leucine rich repeat
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