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    Tgfbr3 transforming growth factor, beta receptor III [ Mus musculus (house mouse) ]

    Gene ID: 21814, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tgfbr3provided by MGI
    Official Full Name
    transforming growth factor, beta receptor IIIprovided by MGI
    Primary source
    MGI:MGI:104637
    See related
    Ensembl:ENSMUSG00000029287 AllianceGenome:MGI:104637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TBRIII; 1110036H20Rik
    Summary
    Enables several functions, including PDZ domain binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity. Involved in several processes, including definitive erythrocyte differentiation; heart development; and positive regulation of SMAD protein signal transduction. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and vasculogenesis. Located in cell surface and endoplasmic reticulum. Is expressed in several structures, including central nervous system; early conceptus; gonad; heart; and jaw. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 38.6), bladder adult (RPKM 20.1) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tgfbr3 in Genome Data Viewer
    Location:
    5 E5; 5 51.9 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (107254433..107437495, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (107106567..107289629, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33474 Neighboring gene STARR-seq mESC enhancer starr_13883 Neighboring gene predicted gene, 42146 Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_13887 Neighboring gene predicted gene, 22557 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:107786881-107787082 Neighboring gene STARR-positive B cell enhancer mm9_chr5:107788417-107788718 Neighboring gene bromodomain, testis-specific Neighboring gene STARR-seq mESC enhancer starr_13888 Neighboring gene predicted gene 17202 Neighboring gene high mobility group protein B1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SMAD binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables activin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to transforming growth factor beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transforming growth factor beta receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transforming growth factor beta receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transforming growth factor beta receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta receptor activity, type III ISO
    Inferred from Sequence Orthology
    more info
     
    enables transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables type II transforming growth factor beta receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type II transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of apoptotic process involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood vessel diameter maintenance TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in collagen metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in coronary vasculature development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in coronary vasculature morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in definitive erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epicardial cell to mesenchymal cell transition TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epicardium-derived cardiac fibroblast cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart trabecula morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in liver development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of apoptotic process involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to follicle-stimulating hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to luteinizing hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to prostaglandin E ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in secondary palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasculogenesis involved in coronary vascular morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventricular compact myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventricular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visceral serous pericardium development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of inhibin-betaglycan-ActRII complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transforming growth factor beta receptor type 3
    Names
    TGF-beta receptor type 3
    TGF-beta receptor type III
    TGFR-3
    betaglycan

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011578.4NP_035708.2  transforming growth factor beta receptor type 3 precursor

      See identical proteins and their annotated locations for NP_035708.2

      Status: VALIDATED

      Source sequence(s)
      AC133897, AC166776
      Consensus CDS
      CCDS19499.1
      UniProtKB/Swiss-Prot
      O88393, Q6NS72
      UniProtKB/TrEMBL
      A0A0R4J097
      Related
      ENSMUSP00000031224.9, ENSMUST00000031224.15
      Conserved Domains (2) summary
      smart00241
      Location:454723
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:597722
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      107254433..107437495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)