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    Tcf23 transcription factor 23 [ Mus musculus (house mouse) ]

    Gene ID: 69852, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tcf23provided by MGI
    Official Full Name
    transcription factor 23provided by MGI
    Primary source
    MGI:MGI:1934960
    See related
    Ensembl:ENSMUSG00000006642 AllianceGenome:MGI:1934960
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Out; bHLHa24; 2010002O16Rik
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in negative regulation of muscle cell differentiation and negative regulation of transcription by RNA polymerase II. Located in euchromatin. Is expressed in central nervous system and genitourinary system. Orthologous to human TCF23 (transcription factor 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 8.3), ovary adult (RPKM 6.2) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Tcf23 in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31125946..31145406)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30968602..30988062)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in euchromatin PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    transcription factor 23
    Names
    TCF-23
    basic helix-loop-helix transcription factor OUT
    ovary, uterus and testis protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053085.2NP_444315.1  transcription factor 23

      See identical proteins and their annotated locations for NP_444315.1

      Status: PROVISIONAL

      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS19168.1
      UniProtKB/Swiss-Prot
      Q9JLR5
      Related
      ENSMUSP00000006818.3, ENSMUST00000006818.4
      Conserved Domains (1) summary
      smart00353
      Location:82131
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31125946..31145406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504095.4XP_006504158.1  transcription factor 23 isoform X1

      Conserved Domains (1) summary
      cd19709
      Location:77132
      bHLH_TS_TCF23_OUT; basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins
    2. XM_006504096.4XP_006504159.1  transcription factor 23 isoform X2

      Conserved Domains (1) summary
      cd19709
      Location:3388
      bHLH_TS_TCF23_OUT; basic helix-loop-helix (bHLH) domain found in transcription factor 23 (TCF-23) and similar proteins
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