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    Tada2a transcriptional adaptor 2A [ Mus musculus (house mouse) ]

    Gene ID: 217031, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tada2aprovided by MGI
    Official Full Name
    transcriptional adaptor 2Aprovided by MGI
    Primary source
    MGI:MGI:2144471
    See related
    Ensembl:ENSMUSG00000018651 AllianceGenome:MGI:2144471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tada2l; D030022J10Rik
    Summary
    Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Acts upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Located in mitotic spindle and nucleus. Part of ATAC complex. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.3), limb E14.5 (RPKM 12.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Tada2a in Genome Data Viewer
    Location:
    11 C; 11 51.29 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83969746..84020466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84078920..84129644, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene dual specificity phosphatase 14 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene acetyl-Coenzyme A carboxylase alpha Neighboring gene predicted gene 11437 Neighboring gene 60S ribosomal protein L35 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin binding  
    contributes_to histone acetyltransferase activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization PubMed 
    involved_in chromatin remodeling  
    acts_upstream_of_or_within mitotic cell cycle PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of cell cycle PubMed 
    involved_in regulation of cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of cell division PubMed 
    involved_in regulation of cell division  
    involved_in regulation of cell division  
    involved_in regulation of embryonic development PubMed 
    involved_in regulation of embryonic development  
    acts_upstream_of_or_within regulation of protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of protein stability PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of tubulin deacetylation PubMed 
    involved_in regulation of tubulin deacetylation  
    involved_in regulation of tubulin deacetylation  
    Component Evidence Code Pubs
    part_of ATAC complex PubMed 
    part_of ATAC complex  
    part_of SAGA complex  
    part_of SAGA complex PubMed 
    part_of SAGA-type complex  
    located_in mitotic spindle PubMed 
    located_in mitotic spindle PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    transcriptional adapter 2-alpha
    Names
    ADA2-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172562.3NP_766150.1  transcriptional adapter 2-alpha

      See identical proteins and their annotated locations for NP_766150.1

      Status: PROVISIONAL

      Source sequence(s)
      AL596447, AL645615
      Consensus CDS
      CCDS25183.1
      UniProtKB/Swiss-Prot
      Q3TZD7, Q8BNK0, Q8CHV6, Q8R3H5
      Related
      ENSMUSP00000018795.7, ENSMUST00000018795.13
      Conserved Domains (4) summary
      COG5114
      Location:11440
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
      cd00167
      Location:74118
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd02335
      Location:1564
      ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
      pfam04433
      Location:374440
      SWIRM; SWIRM domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      83969746..84020466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532989.5XP_006533052.1  transcriptional adapter 2-alpha isoform X1

      Conserved Domains (1) summary
      COG5114
      Location:11420
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    2. XM_030245845.2XP_030101705.1  transcriptional adapter 2-alpha isoform X2

      UniProtKB/TrEMBL
      B1AT25
      Conserved Domains (1) summary
      COG5114
      Location:1276
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    3. XM_011248932.4XP_011247234.1  transcriptional adapter 2-alpha isoform X3

      Conserved Domains (1) summary
      COG5114
      Location:11272
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    RNA

    1. XR_001779958.3 RNA Sequence

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