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    St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 20444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St3gal2provided by MGI
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by MGI
    Primary source
    MGI:MGI:99427
    See related
    Ensembl:ENSMUSG00000031749 AllianceGenome:MGI:99427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Siat5; ST3GalII
    Summary
    Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Acts upstream of or within protein glycosylation. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Is expressed in several structures, including exocrine gland; genitourinary system; hemolymphoid system gland; intestine; and liver. Orthologous to human ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 32.2), cerebellum adult (RPKM 15.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St3gal2 in Genome Data Viewer
    Location:
    8 E1; 8 57.81 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111646520..111699132)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110919743..110974058)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene fucose kinase Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene STARR-positive B cell enhancer ABC_E8264 Neighboring gene predicted gene, 26132 Neighboring gene predicted gene, 46052 Neighboring gene predicted gene, 39251 Neighboring gene STARR-positive B cell enhancer ABC_E1770 Neighboring gene DEAD box helicase 19a Neighboring gene STARR-seq mESC enhancer starr_22687 Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of autophagy by ST3GAL2-mediated α2-3 sialylated glycosphingolipids in hepatic encephalopathy. Li X, et al. Int J Biol Macromol, 2024 Oct. PMID 39256125
    2. Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance. Lopez PH, et al. Glycobiology, 2017 Jan. PMID 27683310, Free PMC Article
    3. Adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes: a new model for dilated cardiomyopathy. Suzuki O, et al. Proc Jpn Acad Ser B Phys Biol Sci, 2011. PMID 21986317, Free PMC Article
    4. Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum. Blažetić S, et al. Int J Mol Sci, 2023 Dec 7. PMID 38139047, Free PMC Article
    5. Sialylation regulates brain structure and function. Yoo SW, et al. FASEB J, 2015 Jul. PMID 25846372, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of autophagy by ST3GAL2-mediated alpha2-3 sialylated glycosphingolipids in hepatic encephalopathy.
      Title: Regulation of autophagy by ST3GAL2-mediated α2-3 sialylated glycosphingolipids in hepatic encephalopathy.
    2. Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
      Title: Sialyltransferase Mutations Alter the Expression of Calcium-Binding Interneurons in Mice Neocortex, Hippocampus and Striatum.
    3. GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain.
      Title: GT1b functions as a novel endogenous agonist of toll-like receptor 2 inducing neuropathic pain.
    4. t3gal2-null mice display a reduced respiratory exchange ratio compared to WT mice, indicating a preference for lipid oxidation as an energy source. Despite their altered metabolism, St3gal2-null mice were hyperactive. We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity.
      Title: Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance.
    5. St3gal2/3 double-null mice displayed dysmyelination marked by a reduction in major myelin proteins, fewer myelinated axons, a decrease in myelin thickness, possibly by dysregulation of ganglioside-mediated oligodendroglial precursor cell proliferation.
      Title: Sialylation regulates brain structure and function.
    6. An adult onset cardiac dilatation in a transgenic mouse line with Galbeta1,3GalNAc alpha2,3-sialyltransferase II (ST3Gal-II) transgenes, is reported.
      Title: Adult onset cardiac dilatation in a transgenic mouse line with Galβ1,3GalNAc α2,3-sialyltransferase II (ST3Gal-II) transgenes: a new model for dilated cardiomyopathy.
    7. was not found to play a role in regulating synthesis of selectin ligands nor in vitro rolling of marrow-derived neutrophils on E- or P-selectins presented by Chinese hamster ovary cells
      Title: Sialyltransferase specificity in selectin ligand formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ganglioside biosynthetic process via lactosylceramide IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process via lactosylceramide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process via lactosylceramide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in globoside biosynthetic process via lactosylceramide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in globoside biosynthetic process via lactosylceramide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sialylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
    Names
    SIAT4-B
    ST3Gal II
    ST3GalA.2
    alpha 2,3-ST 2
    beta-galactoside alpha-2,3-sialyltransferase 2
    gal-NAc6S
    gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
    monosialoganglioside sialyltransferase
    sialyltransferase 4B
    sialyltransferase 5
    NP_001411820.1
    NP_001411821.1
    NP_033205.2
    XP_006530850.1
    XP_006530851.1
    XP_036009743.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424891.1 → NP_001411820.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      AC132945
      UniProtKB/Swiss-Prot
      Q11204, Q8BPL0
      UniProtKB/TrEMBL
      Q8BSA0, Q91WH6

    2. NM_001424892.1 → NP_001411821.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      AC132945
      UniProtKB/Swiss-Prot
      Q11204, Q8BPL0
      UniProtKB/TrEMBL
      Q8BSA0, Q91WH6

    3. NM_009179.4 → NP_033205.2  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

      See identical proteins and their annotated locations for NP_033205.2

      Status: VALIDATED

      Source sequence(s)
      AC132945
      Consensus CDS
      CCDS22667.1
      UniProtKB/Swiss-Prot
      Q11204, Q8BPL0
      UniProtKB/TrEMBL
      Q8BSA0, Q91WH6
      Related
      ENSMUSP00000034197.5, ENSMUST00000034197.5
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111646520..111699132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530787.4 → XP_006530850.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530850.1

      UniProtKB/Swiss-Prot
      Q11204, Q8BPL0
      UniProtKB/TrEMBL
      Q8BSA0, Q91WH6
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006530788.3 → XP_006530851.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530851.1

      UniProtKB/Swiss-Prot
      Q11204, Q8BPL0
      UniProtKB/TrEMBL
      Q8BSA0, Q91WH6
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_036153850.1 → XP_036009743.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q11204, Q8BPL0
      UniProtKB/TrEMBL
      Q8BSA0, Q91WH6
      Conserved Domains (1) summary
      pfam00777
      Location:94 → 348
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11204.2 GenPept UniProtKB/Swiss-Prot:Q11204

    Gene LinkOut

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