Raet1e retinoic acid early transcript 1E [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Raet1eprovided by MGI
Official Full Name: retinoic acid early transcript 1Eprovided by MGI
Primary source: MGI:MGI:2675273
See related: Ensembl:ENSMUSG00000053219 AllianceGenome:MGI:2675273
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within T cell mediated cytotoxicity. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in embryo; embryo endoderm; and midgut. Orthologous to human RAET1G (retinoic acid early transcript 1G) and RAET1L (retinoic acid early transcript 1L). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver adult (RPKM 1.1), bladder adult (RPKM 0.9) and 21 other tissues See more
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Genomic context

Location:: 10 A3; 10 9.89 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (22034441..22059820)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (22158542..22189697)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports that retinoic acid early induced transcript-1-d and retinoic acid early induced transcript-1-e (Raet1) genes are induced early upon experimental autoimmune encephalomyelitis onset and reach a maximal expression at the peak of the pathology. Study also shows that macrophages as well as microglia, are cellular sources of Raet1 transcripts.
Title: RAE-1 expression is induced during experimental autoimmune encephalomyelitis and is correlated with microglia cell proliferation.
CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1epsilon transgenic mice.
Title: CD4(+) NKG2D(+) T cells induce NKG2D down-regulation in natural killer cells in CD86-RAE-1ε transgenic mice.
Reveal Raet1e, a major histocompatibility complex class 1-like molecule expressed in lesional aortic endothelial cells and macrophage-rich regions, as a novel atherosclerosis gene.
Title: Altered expression of Raet1e, a major histocompatibility complex class 1-like molecule, underlies the atherosclerosis modifier locus Ath11 10b.
Raet1e genes are directly transcriptionally activated by E2F family transcription factors, which play a central role in regulating cell cycle entry.
Title: RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry.
RAE1 expression was sufficient to induce the recruitment of adoptively transferred CTLs to islets.
Title: RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Markers

Raet1a (e-PCR), detects polymorphism
- UniSTS:257028

MHAa87e7.seq (e-PCR)
- UniSTS:125424

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables natural killer cell lectin-like receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables natural killer cell lectin-like receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid early-inducible protein 1-epsilon

Names: Rae-1 epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359808.1 → NP_001346737.1 retinoic acid early-inducible protein 1-epsilon precursor

Status: VALIDATED

Source sequence(s)

AK012289, AK131854, FJ594067

Consensus CDS

CCDS35865.1

UniProtKB/Swiss-Prot

A2RSZ5, Q9CZQ6

UniProtKB/TrEMBL

D7F2B6

Related

ENSMUSP00000138022.2, ENSMUST00000181645.8

Conserved Domains (1) summary

cl08246
Location:31 → 202

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_001359809.1 → NP_001346738.1 retinoic acid early-inducible protein 1-epsilon precursor

Status: VALIDATED

Source sequence(s)

AK012289, AK131854, FJ594067

Consensus CDS

CCDS35865.1

UniProtKB/Swiss-Prot

A2RSZ5, Q9CZQ6

UniProtKB/TrEMBL

D7F2B6

Conserved Domains (1) summary

cl08246
Location:31 → 202

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_198193.3 → NP_937836.1 retinoic acid early-inducible protein 1-epsilon precursor

See identical proteins and their annotated locations for NP_937836.1

Status: VALIDATED

Source sequence(s)

AK012289, CV561218, FJ594067

Consensus CDS

CCDS35865.1

UniProtKB/Swiss-Prot

A2RSZ5, Q9CZQ6

UniProtKB/TrEMBL

D7F2B6

Related

ENSMUSP00000066627.5, ENSMUST00000065527.11

Conserved Domains (1) summary

cl08246
Location:31 → 202

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

22034441..22059820

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512780.3 → XP_006512843.1 retinoic acid early-inducible protein 1-epsilon isoform X1

See identical proteins and their annotated locations for XP_006512843.1

UniProtKB/Swiss-Prot

A2RSZ5, Q9CZQ6

UniProtKB/TrEMBL

D7F2B6

Conserved Domains (1) summary

cl08246
Location:31 → 202

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
XM_011243179.1 → XP_011241481.1 retinoic acid early-inducible protein 1-epsilon isoform X1

See identical proteins and their annotated locations for XP_011241481.1

UniProtKB/Swiss-Prot

A2RSZ5, Q9CZQ6

UniProtKB/TrEMBL

D7F2B6

Conserved Domains (1) summary

cl08246
Location:31 → 202

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
XM_006512782.2 → XP_006512845.1 retinoic acid early-inducible protein 1-epsilon isoform X1

See identical proteins and their annotated locations for XP_006512845.1

UniProtKB/Swiss-Prot

A2RSZ5, Q9CZQ6

UniProtKB/TrEMBL

D7F2B6

Related

ENSMUSP00000136032.2, ENSMUST00000178026.2

Conserved Domains (1) summary

cl08246
Location:31 → 202

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2