Raet1c retinoic acid early transcript gamma [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Raet1cprovided by MGI
Official Full Name: retinoic acid early transcript gammaprovided by MGI
Primary source: MGI:MGI:109431
See related: AllianceGenome:MGI:109431
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rae1c; RAE-1gamma
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within cellular response to exogenous dsRNA; cellular response to lipopolysaccharide; and defense response to bacterium. Located in external side of plasma membrane. Is expressed in several structures, including branchial arch; heart; liver; placenta; and spleen. Orthologous to human RAET1G (retinoic acid early transcript 1G) and RAET1L (retinoic acid early transcript 1L). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: not in current annotation release
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Genomic context

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Location:: 10 A3; 10 9.89 cM

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1gamma by intracellular retention and cell surface masking.
Title: The murine cytomegalovirus immunoevasin gp40/m152 inhibits NKG2D receptor RAE-1γ by intracellular retention and cell surface masking.
Vectors expressing RAE-1gamma represent a promising approach in the development of CD8 T-cell-based vaccines.
Title: Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ.
RAE1d, not Raet1c, is resistant to downregulation by mouse cytomegalovirus.
Title: Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

Raet1a (e-PCR), detects polymorphism
- UniSTS:257028

Raet1a (e-PCR), detects polymorphism
- UniSTS:256449

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables natural killer cell lectin-like receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinoic acid early-inducible protein 1-gamma

Names: RAE-1-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009018.1 → NP_033044.1 retinoic acid early-inducible protein 1-gamma precursor

See identical proteins and their annotated locations for NP_033044.1

Status: PROVISIONAL

Source sequence(s)

D64162

UniProtKB/Swiss-Prot

A2RSA1, O08604

Conserved Domains (1) summary

pfam14586
Location:31 → 204

MHC_I_2; Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2