Pwp2 PWP2 periodic tryptophan protein homolog (yeast) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pwp2provided by MGI
Official Full Name: PWP2 periodic tryptophan protein homolog (yeast)provided by MGI
Primary source: MGI:MGI:1341200
See related: Ensembl:ENSMUSG00000032834 AllianceGenome:MGI:1341200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pwp2h; wdp103; 6530411D08Rik
Summary: Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be located in nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human PWP2 (PWP2 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 6.6), CNS E18 (RPKM 6.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (78006743..78021005, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (78170909..78185171, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gabrb1 (e-PCR), detects polymorphism
- UniSTS:143152

Pwp2h (e-PCR), detects polymorphism
- UniSTS:259134

NoName (e-PCR)
- UniSTS:236385

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: periodic tryptophan protein 2 homolog

Names: WD-repeat protein p103

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029546.2 → NP_083822.1 periodic tryptophan protein 2 homolog

See identical proteins and their annotated locations for NP_083822.1

Status: PROVISIONAL

Source sequence(s)

AK088254

Consensus CDS

CCDS35958.1

UniProtKB/Swiss-Prot

Q8BTR0, Q8BU03

UniProtKB/TrEMBL

Q2M1K2, Q8R538

Related

ENSMUSP00000045812.10, ENSMUST00000042556.11

Conserved Domains (5) summary

COG2319
Location:277 → 643

WD40; WD40 repeat [General function prediction only]

cd00200
Location:322 → 629

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam04003
Location:771 → 873

Utp12; Dip2/Utp12 Family

sd00039
Location:333 → 371

7WD40; WD40 repeat [structural motif]

cl02567
Location:20 → 401

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...