Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn7provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 7provided by MGI
Primary source: MGI:MGI:2156893
See related: Ensembl:ENSMUSG00000031506 AllianceGenome:MGI:2156893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LPTP; HEPTP; BPTP-4; LC-PTP; C920001D21Rik
Summary: Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and mitotic spindle. Is expressed in liver and thymus primordium. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 47.9), spleen adult (RPKM 10.4) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 58.24 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (135059577..135073064)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (135131838..135145328)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTPN7 regulates platelet functional responses downstream of GPCR agonists, but not GPVI agonists, through inhibition of ERK activation and thromboxane generation.
Title: The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets.
PTPN7 as a negative regulator of TNF-alpha expression and the inflammatory response in macrophages
Title: Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages.
beta(2)AR stimulation on a B cell phosphorylates and inactivates HePTP in a Gs/cAMP/PKA-dependent manner to release bound p38 MAPK, making more available for phosphorylation and subsequent IgE regulation.
Title: Hematopoietic protein tyrosine phosphatase mediates beta2-adrenergic receptor-induced regulation of p38 mitogen-activated protein kinase in B lymphocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 7

Names: hematopoietic protein-tyrosine phosphatase

NP_001343311.1

EC 3.1.3.48

NP_796055.1

EC 3.1.3.48

XP_006529759.1

EC 3.1.3.48

XP_006529761.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356382.1 → NP_001343311.1 tyrosine-protein phosphatase non-receptor type 7

Status: VALIDATED

Source sequence(s)

AC133097

Consensus CDS

CCDS15315.1

UniProtKB/Swiss-Prot

Q8BUM3

UniProtKB/TrEMBL

B7ZNE1

Related

ENSMUSP00000129474.2, ENSMUST00000167080.3

Conserved Domains (1) summary

cd14612
Location:105 → 349

PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7
NM_177081.4 → NP_796055.1 tyrosine-protein phosphatase non-receptor type 7

See identical proteins and their annotated locations for NP_796055.1

Status: VALIDATED

Source sequence(s)

AC133097

Consensus CDS

CCDS15315.1

UniProtKB/Swiss-Prot

Q8BUM3

UniProtKB/TrEMBL

B7ZNE1

Related

ENSMUSP00000045803.5, ENSMUST00000049449.11

Conserved Domains (1) summary

cd14612
Location:105 → 349

PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

135059577..135073064

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529698.5 → XP_006529761.1 tyrosine-protein phosphatase non-receptor type 7 isoform X1

See identical proteins and their annotated locations for XP_006529761.1

UniProtKB/Swiss-Prot

Q8BUM3

UniProtKB/TrEMBL

B7ZNE1

Conserved Domains (1) summary

cd14612
Location:105 → 349

PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7
XM_006529696.5 → XP_006529759.1 tyrosine-protein phosphatase non-receptor type 7 isoform X1

See identical proteins and their annotated locations for XP_006529759.1

UniProtKB/Swiss-Prot

Q8BUM3

UniProtKB/TrEMBL

B7ZNE1

Related

ENSMUSP00000141133.2, ENSMUST00000187985.7

Conserved Domains (1) summary

cd14612
Location:105 → 349

PTPc-N7; catalytic domain of tyrosine-protein phosphatase non-receptor type 7