Pop4 processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pop4provided by MGI
Official Full Name: processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae)provided by MGI
Primary source: MGI:MGI:1913411
See related: Ensembl:ENSMUSG00000030423 AllianceGenome:MGI:1913411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rpp29; 1110023P21Rik
Summary: Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in rRNA processing and tRNA 5'-leader removal. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of multimeric ribonuclease P complex and ribonuclease MRP complex. Is expressed in sensory organ and skeleton. Orthologous to human POP4 (POP4 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 23.9), CNS E14 (RPKM 20.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 25.36 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (37962239..37970803, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (38262812..38271393, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two genes, Atp4a and Pop4, fulfilled the criteria from our candidate gene approaches. The knockdown of both genes in MIN6 cells led to decreased glucose-stimulated insulin secretion, indicating a regulatory role of both genes in insulin secretion, thereby possibly contributing to the phenotype linked to Nbg7p
Title: Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ribonuclease P RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease P RNA binding	ISO Inferred from Sequence Orthology more info
enables ribonuclease P RNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to ribonuclease P activity	ISO Inferred from Sequence Orthology more info
contributes_to ribonuclease P activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA 5'-leader removal	ISO Inferred from Sequence Orthology more info
involved_in tRNA 5'-leader removal	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of multimeric ribonuclease P complex	ISO Inferred from Sequence Orthology more info
part_of multimeric ribonuclease P complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of ribonuclease MRP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonuclease MRP complex	IEA Inferred from Electronic Annotation more info
part_of ribonuclease P complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribonuclease P protein subunit p29

Names: POP4 (processing of precursor , S. cerevisiae) homolog

NP_079666.1

EC 3.1.26.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.