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    Nudt15 nudix hydrolase 15 [ Mus musculus (house mouse) ]

    Gene ID: 214254, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nudt15provided by MGI
    Official Full Name
    nudix hydrolase 15provided by MGI
    Primary source
    MGI:MGI:2443366
    See related
    Ensembl:ENSMUSG00000033405 AllianceGenome:MGI:2443366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTH2; 6530403O17; A730068G11Rik
    Summary
    Enables 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity. Acts upstream of or within purine deoxyribonucleoside triphosphate catabolic process and response to reactive oxygen species. Predicted to be active in cytosol. Used to study leukopenia; neutropenia; and pancytopenia. Human ortholog(s) of this gene implicated in thiopurine S-methyltransferase deficiency. Orthologous to human NUDT15 (nudix hydrolase 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 1.7), heart adult (RPKM 1.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nudt15 in Genome Data Viewer
    Location:
    14 D3; 14 39.06 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (73756320..73785682, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (73518880..73548242, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7336 Neighboring gene predicted gene 4266 Neighboring gene STARR-positive B cell enhancer ABC_E936 Neighboring gene STARR-positive B cell enhancer ABC_E9408 Neighboring gene STARR-seq mESC enhancer starr_37120 Neighboring gene mediator complex subunit 4 Neighboring gene predicted gene, 41209 Neighboring gene STARR-positive B cell enhancer ABC_E3125 Neighboring gene STARR-seq mESC enhancer starr_37122 Neighboring gene succinate-Coenzyme A ligase, ADP-forming, beta subunit Neighboring gene predicted gene, 24540

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA protection IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA protection ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dGTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dGTP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dGTP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nucleoside phosphate catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within purine deoxyribonucleoside triphosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in purine nucleotide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in purine nucleotide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of proteasomal protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    nucleotide triphosphate diphosphatase NUDT15
    Names
    7,8-dihydro-8-oxoguanine-triphosphatase NUDT15
    8-oxo-dGTPase NUDT15
    MutT homolog 2
    nucleoside diphosphate-linked moiety X motif 15
    nucleoside diphosphate-linked to another moiety X hydrolase 15
    nudix (nucleoside diphosphate linked moiety X)-type motif 15
    nudix motif 15
    probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15
    probable 8-oxo-dGTP diphosphatase NUDT15
    NP_001347413.1
    NP_766115.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360484.1NP_001347413.1  nucleotide triphosphate diphosphatase NUDT15

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant, but shorter, transcript. It has a transcriptional start site that is internal relative to that of variant 2. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC113198, AK032657, AK040749, AK043196, BY267802
      Consensus CDS
      CCDS27270.1
      UniProtKB/Swiss-Prot
      Q8BG93
      UniProtKB/TrEMBL
      Q3TH44
      Conserved Domains (1) summary
      cd04678
      Location:27142
      Nudix_Hydrolase_19; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    2. NM_172527.3NP_766115.1  nucleotide triphosphate diphosphatase NUDT15

      See identical proteins and their annotated locations for NP_766115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC113198, AK032657, AK040749, AK043196
      Consensus CDS
      CCDS27270.1
      UniProtKB/Swiss-Prot
      Q8BG93
      UniProtKB/TrEMBL
      Q3TH44
      Related
      ENSMUSP00000039537.2, ENSMUST00000043813.3
      Conserved Domains (1) summary
      cd04678
      Location:27142
      Nudix_Hydrolase_19; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      73756320..73785682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)