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    Mixl1 Mix paired-like homeobox [ Mus musculus (house mouse) ]

    Gene ID: 27217, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mixl1provided by MGI
    Official Full Name
    Mix paired-like homeoboxprovided by MGI
    Primary source
    MGI:MGI:1351322
    See related
    Ensembl:ENSMUSG00000026497 AllianceGenome:MGI:1351322
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mm1; Mml
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in several processes, including endodermal cell differentiation; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of mesoderm development. Acts upstream of or within several processes, including digestive tract development; gastrulation; and hemopoiesis. Located in chromatin and nucleus. Is expressed in several structures, including early embryo; egg cylinder; embryo mesoderm; metanephros; and primitive streak. Orthologous to human MIXL1 (Mix paired-like homeobox). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Mixl1 in Genome Data Viewer
    Location:
    1 H4; 1 84.46 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180520608..180524599, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (180693043..180697034, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53485 Neighboring gene lin-9 DREAM MuvB core complex component Neighboring gene acyl-Coenzyme A binding domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:182694146-182694255 Neighboring gene predicted gene, 38293

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within endoderm formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within hemopoiesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of hematopoietic progenitor cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mesoderm development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mesoderm development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein MIXL1
    Names
    MIX1 homeobox-like protein 1
    Mix1 homeobox-like 1
    homeodomain protein MIX
    mMix
    mix.1 homeobox-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013729.3NP_038757.1  homeobox protein MIXL1

      See identical proteins and their annotated locations for NP_038757.1

      Status: VALIDATED

      Source sequence(s)
      AC167020, BC099877
      Consensus CDS
      CCDS15571.1
      UniProtKB/Swiss-Prot
      Q9QZ61, Q9WUI0
      Related
      ENSMUSP00000027778.8, ENSMUST00000027778.8
      Conserved Domains (1) summary
      pfam00046
      Location:89142
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180520608..180524599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)