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    Ly6h lymphocyte antigen 6 family member H [ Mus musculus (house mouse) ]

    Gene ID: 23934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ly6hprovided by MGI
    Official Full Name
    lymphocyte antigen 6 family member Hprovided by MGI
    Primary source
    MGI:MGI:1346030
    See related
    Ensembl:ENSMUSG00000022577 AllianceGenome:MGI:1346030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Acts upstream of or within acetylcholine receptor signaling pathway. Predicted to be located in side of membrane and synapse. Predicted to be active in plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 141.2), whole brain E14.5 (RPKM 99.2) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ly6h in Genome Data Viewer
    Location:
    15 D3; 15 34.52 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75436594..75439114, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75564745..75569470, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34593 Neighboring gene predicted gene, 34646 Neighboring gene GPI-anchored HDL-binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1174 Neighboring gene zinc finger protein 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of mouse Ly6H and its expression in normal tissue. Apostolopoulos J, et al. Immunogenetics, 1999 Oct. PMID 10501842
    2. Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling. Puddifoot CA, et al. J Neurosci, 2015 Feb 25. PMID 25716842, Free PMC Article
    3. Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane. Moriwaki Y, et al. Sci Rep, 2020 Jul 20. PMID 32686737, Free PMC Article
    4. Mouse Ly-6 proteins and their extended family: markers of cell differentiation and regulators of cell signaling. Bamezai A. Arch Immunol Ther Exp (Warsz), 2004 Jul-Aug. PMID 15467490
    5. Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development. Dessaud E, et al. Mol Cell Neurosci, 2006 Feb. PMID 16236524

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane.
      Title: Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane.
    2. Ly6h regulates alpha7 nAChRs cell-surface expression and nicotine-induced potentiation of glutamatergic mEPSC.
      Title: Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine receptor inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine receptor inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lymphocyte antigen 6H
    Names
    ly-6H
    lymphocyte antigen 6 complex, locus H

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135688.2 → NP_001129160.1  lymphocyte antigen 6H isoform b precursor

      See identical proteins and their annotated locations for NP_001129160.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
      Source sequence(s)
      AC121359
      Consensus CDS
      CCDS49640.1
      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1
      Related
      ENSMUSP00000070646.9, ENSMUST00000065417.15
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    2. NM_001135689.2 → NP_001129161.1  lymphocyte antigen 6H isoform b precursor

      See identical proteins and their annotated locations for NP_001129161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
      Source sequence(s)
      AC121359
      Consensus CDS
      CCDS49640.1
      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1
      Related
      ENSMUSP00000023241.6, ENSMUST00000023241.12
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    3. NM_001411856.1 → NP_001398785.1  lymphocyte antigen 6H isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode the same isoform (a).
      Source sequence(s)
      AC121359
      UniProtKB/TrEMBL
      Q8K356
      Related
      ENSMUSP00000122878.2, ENSMUST00000156032.2

    4. NM_001411857.1 → NP_001398786.1  lymphocyte antigen 6H isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
      Source sequence(s)
      AC121359
      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1

    5. NM_001411858.1 → NP_001398787.1  lymphocyte antigen 6H isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
      Source sequence(s)
      AC121359
      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1

    6. NM_011837.4 → NP_035967.1  lymphocyte antigen 6H isoform a precursor

      See identical proteins and their annotated locations for NP_035967.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 4 encode the same isoform (a).
      Source sequence(s)
      AC121359
      Consensus CDS
      CCDS27544.1
      UniProtKB/TrEMBL
      Q8K356
      Related
      ENSMUSP00000122061.2, ENSMUST00000127095.8
      Conserved Domains (1) summary
      pfam00021
      Location:49 → 131
      UPAR_LY6; u-PAR/Ly-6 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      75436594..75439114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248535.1 → XP_030104395.1  lymphocyte antigen 6H isoform X3

      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    2. XM_030248536.2 → XP_030104396.1  lymphocyte antigen 6H isoform X3

      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain

    3. XM_006520901.2 → XP_006520964.1  lymphocyte antigen 6H isoform X3

      See identical proteins and their annotated locations for XP_006520964.1

      UniProtKB/Swiss-Prot
      Q9WUC3
      UniProtKB/TrEMBL
      Q544M1
      Conserved Domains (1) summary
      pfam00021
      Location:28 → 110
      UPAR_LY6; u-PAR/Ly-6 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUC3.2 GenPept UniProtKB/Swiss-Prot:Q9WUC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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