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    Trrap transformation/transcription domain-associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trrapprovided by RGD
    Official Full Name
    transformation/transcription domain-associated proteinprovided by RGD
    Primary source
    RGD:1305446
    See related
    EnsemblRapid:ENSRNOG00000025244 AllianceGenome:RGD:1305446
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables chromatin binding activity. Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 261.4), Spleen (RPKM 152.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trrap in Genome Data Viewer
    Location:
    12p11
    Exon count:
    74
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (14851758..14941444, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9738006..9827708, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11537950..11627563, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 7 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134481264 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nucleolar RNA ZL1 Neighboring gene transmembrane protein 130 Neighboring gene transfer RNA serine (anticodon AGA) 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Herceg Z, et al. Nat Genet, 2001 Oct. PMID 11544477
    2. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Frank SR, et al. Genes Dev, 2001 Aug 15. PMID 11511539, Free PMC Article
    3. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. McMahon SB, et al. Cell, 1998 Aug 7. PMID 9708738
    4. E2F transcriptional activation requires TRRAP and GCN5 cofactors. Lang SE, et al. J Biol Chem, 2001 Aug 31. PMID 11418595
    5. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Ikura T, et al. Cell, 2000 Aug 18. PMID 10966108

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Swr1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transformation/transcription domain-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105907.4 → NP_001099377.2  transformation/transcription domain-associated protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6GLC1
      Conserved Domains (3) summary
      cd05163
      Location:3483 → 3770
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2833 → 3173
      FAT; FAT domain
      pfam02260
      Location:3819 → 3846
      FATC; FATC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      14851758..14941444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089172.2 → XP_038945100.1  transformation/transcription domain-associated protein isoform X17

      UniProtKB/TrEMBL
      A0A8I6GLC1
      Conserved Domains (3) summary
      COG5032
      Location:2526 → 3847
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:3484 → 3771
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2832 → 3174
      FAT; FAT domain

    2. XM_063271123.1 → XP_063127193.1  transformation/transcription domain-associated protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6GLC1

    3. XM_039089174.2 → XP_038945102.1  transformation/transcription domain-associated protein isoform X19

      UniProtKB/TrEMBL
      A0A8I6GLC1
      Related
      ENSRNOP00000095828.1, ENSRNOT00000076323.4
      Conserved Domains (3) summary
      COG5032
      Location:2527 → 3848
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:3485 → 3772
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2833 → 3175
      FAT; FAT domain

    4. XM_063271132.1 → XP_063127202.1  transformation/transcription domain-associated protein isoform X14

      UniProtKB/TrEMBL
      A0A8I6GLC1

    5. XM_063271128.1 → XP_063127198.1  transformation/transcription domain-associated protein isoform X10

      UniProtKB/TrEMBL
      A0A8I6GLC1

    6. XM_039089173.2 → XP_038945101.1  transformation/transcription domain-associated protein isoform X18

      UniProtKB/TrEMBL
      A0A8I5Y6J8
      Related
      ENSRNOP00000095357.2, ENSRNOT00000030545.9
      Conserved Domains (3) summary
      COG5032
      Location:2545 → 3877
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:3514 → 3801
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2851 → 3204
      FAT; FAT domain

    7. XM_063271125.1 → XP_063127195.1  transformation/transcription domain-associated protein isoform X7

      UniProtKB/TrEMBL
      A0A8I6GLC1

    8. XM_063271124.1 → XP_063127194.1  transformation/transcription domain-associated protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6GLC1

    9. XM_063271134.1 → XP_063127204.1  transformation/transcription domain-associated protein isoform X16

      UniProtKB/TrEMBL
      A0A8I5Y6J8, A0A8I6AL99

    10. XM_063271127.1 → XP_063127197.1  transformation/transcription domain-associated protein isoform X9

      UniProtKB/TrEMBL
      A0A8I6GLC1
      Related
      ENSRNOP00000111242.1, ENSRNOT00000166774.1

    11. XM_063271133.1 → XP_063127203.1  transformation/transcription domain-associated protein isoform X15

      UniProtKB/TrEMBL
      A0A8I5Y6J8

    12. XM_063271126.1 → XP_063127196.1  transformation/transcription domain-associated protein isoform X8

      UniProtKB/TrEMBL
      A0A8I6GLC1

    13. XM_063271131.1 → XP_063127201.1  transformation/transcription domain-associated protein isoform X13

      UniProtKB/TrEMBL
      A0A8I5Y6J8
      Related
      ENSRNOP00000076944.2, ENSRNOT00000091346.3

    14. XM_039089162.2 → XP_038945090.1  transformation/transcription domain-associated protein isoform X5

      UniProtKB/TrEMBL
      A0A8I6GLC1
      Conserved Domains (3) summary
      COG5032
      Location:2552 → 3910
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:3521 → 3834
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2858 → 3211
      FAT; FAT domain

    15. XM_063271122.1 → XP_063127192.1  transformation/transcription domain-associated protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6GLC1

    16. XM_039089168.2 → XP_038945096.1  transformation/transcription domain-associated protein isoform X12

      UniProtKB/TrEMBL
      A0A8I5Y6J8
      Conserved Domains (3) summary
      COG5032
      Location:2552 → 3885
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:3522 → 3809
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2858 → 3211
      FAT; FAT domain

    17. XM_063271130.1 → XP_063127200.1  transformation/transcription domain-associated protein isoform X11

      UniProtKB/TrEMBL
      A0A8I5Y6J8

    18. XM_039089159.2 → XP_038945087.1  transformation/transcription domain-associated protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6GLC1
      Conserved Domains (3) summary
      COG5032
      Location:2552 → 3911
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd05163
      Location:3522 → 3835
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
      pfam02259
      Location:2858 → 3211
      FAT; FAT domain

    19. XM_063271119.1 → XP_063127189.1  transformation/transcription domain-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLC1

    20. XM_063271121.1 → XP_063127191.1  transformation/transcription domain-associated protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLC1
    Nucleotide Protein Strain
    Heading Accession and Version

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