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    Lama1 laminin, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 16772, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lama1provided by MGI
    Official Full Name
    laminin, alpha 1provided by MGI
    Primary source
    MGI:MGI:99892
    See related
    Ensembl:ENSMUSG00000032796 AllianceGenome:MGI:99892
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lama
    Summary
    Enables glycosphingolipid binding activity. An extracellular matrix structural constituent. Involved in protein phosphorylation. Acts upstream of or within several processes, including morphogenesis of an epithelium; neuron projection development; and retinal blood vessel morphogenesis. Located in basement membrane and cell-cell junction. Part of laminin-1 complex. Is expressed in several structures, including alimentary system; early conceptus; eye; genitourinary system; and nervous system. Orthologous to human LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 19.3), placenta adult (RPKM 10.0) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lama1 in Genome Data Viewer
    Location:
    17 E1.1; 17 38.8 cM
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68004129..68129640)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (67697127..67822645)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43094 Neighboring gene predicted gene, 36201 Neighboring gene STARR-seq mESC enhancer starr_43095 Neighboring gene STARR-seq mESC enhancer starr_43096 Neighboring gene predicted gene, 52321 Neighboring gene leucine rich repeat containing 30 Neighboring gene Rho GTPase activating protein 28 Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables extracellular matrix structural constituent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables glycosphingolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood vessel morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in camera-type eye development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within morphogenesis of an epithelial sheet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of integrin-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of muscle cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of basement membrane organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retinal blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basement membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in basement membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of laminin-1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of laminin-3 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of laminin-3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein complex involved in cell-matrix adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    laminin subunit alpha-1
    Names
    S-LAM alpha
    S-laminin subunit alpha
    laminin A chain
    laminin-1 subunit alpha
    laminin-3 subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008480.2NP_032506.2  laminin subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_032506.2

      Status: VALIDATED

      Source sequence(s)
      AC154823, AK051116, CA535780, CN461817, CN535171, J04064
      Consensus CDS
      CCDS37681.1
      UniProtKB/Swiss-Prot
      F8VQ40, P19137
      Related
      ENSMUSP00000043957.8, ENSMUST00000035471.9
      Conserved Domains (10) summary
      smart00136
      Location:25275
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:9581002
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:15161553
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:29003053
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00053
      Location:909955
      Laminin_EGF; Laminin EGF domain
      pfam00054
      Location:27512880
      Laminin_G_1; Laminin G domain
      pfam06009
      Location:20182152
      Laminin_II; Laminin Domain II
      pfam00052
      Location:575714
      Laminin_B; Laminin B (Domain IV)
      pfam06008
      Location:15821837
      Laminin_I; Laminin Domain I
      cl25642
      Location:18272064
      DUF390; Protein of unknown function (DUF390)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      68004129..68129640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523718.5XP_006523781.1  laminin subunit alpha-1 isoform X3

      Conserved Domains (5) summary
      smart00136
      Location:25275
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:9581002
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00055
      Location:15161553
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      pfam00052
      Location:575714
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:909955
      Laminin_EGF; Laminin EGF domain
    2. XM_006523717.5XP_006523780.1  laminin subunit alpha-1 isoform X1

      Conserved Domains (10) summary
      smart00136
      Location:25275
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:9581002
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG4372
      Location:17372044
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd00055
      Location:15161553
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:23142470
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:15821837
      Laminin_I; Laminin Domain I
      pfam00054
      Location:27512880
      Laminin_G_1; Laminin G domain
      pfam00052
      Location:575714
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:909955
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:20182152
      Laminin_II; Laminin Domain II
    3. XM_030249517.2XP_030105377.1  laminin subunit alpha-1 isoform X2

      Conserved Domains (10) summary
      smart00180
      Location:713757
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG4372
      Location:14921799
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd00055
      Location:12711308
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:26552808
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:13371592
      Laminin_I; Laminin Domain I
      pfam00054
      Location:25062635
      Laminin_G_1; Laminin G domain
      pfam00052
      Location:330469
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:664710
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:17731907
      Laminin_II; Laminin Domain II
      cl02806
      Location:730
      Laminin_N; Laminin N-terminal (Domain VI)
    4. XM_030249518.2XP_030105378.1  laminin subunit alpha-1 isoform X2

      Conserved Domains (10) summary
      smart00180
      Location:713757
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      COG4372
      Location:14921799
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd00055
      Location:12711308
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00110
      Location:26552808
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06008
      Location:13371592
      Laminin_I; Laminin Domain I
      pfam00054
      Location:25062635
      Laminin_G_1; Laminin G domain
      pfam00052
      Location:330469
      Laminin_B; Laminin B (Domain IV)
      pfam00053
      Location:664710
      Laminin_EGF; Laminin EGF domain
      pfam06009
      Location:17731907
      Laminin_II; Laminin Domain II
      cl02806
      Location:730
      Laminin_N; Laminin N-terminal (Domain VI)