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    Kir3dl1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 [ Mus musculus (house mouse) ]

    Gene ID: 245616, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kir3dl1provided by MGI
    Official Full Name
    killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1provided by MGI
    Primary source
    MGI:MGI:2652397
    See related
    Ensembl:ENSMUSG00000031424 AllianceGenome:MGI:2652397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Krl1; Kirl1; Kirl2
    Summary
    Predicted to enable several functions, including MHC class Ib protein binding activity; MHC class Ib receptor activity; and identical protein binding activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to be located in early endosome membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Polyomavirus-associated nephropathy; West Nile fever; human immunodeficiency virus infectious disease (multiple); liver disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including KIR3DL1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1) and KIR3DL2 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Kir3dl1 in Genome Data Viewer
    Location:
    X F1; X 58.77 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (135418748..135435055)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (136517999..136534306)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA alanine 4 (anticodon TGC) Neighboring gene predicted gene 14991 Neighboring gene killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 Neighboring gene presenilin associated, rhomboid-like pseudogene Neighboring gene nuclear encoded tRNA alanine 3 (anticodon TGC)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class Ib protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MHC class Ib receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    killer cell immunoglobulin-like receptor 3DL1
    Names
    KIR-like receptor 1
    killer cell immunoglobulin-like receptor Kir3dl1
    killer immunoglobulin receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310690.1NP_001297619.1  killer cell immunoglobulin-like receptor 3DL1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AL672068, AY152727, AY530782
      Consensus CDS
      CCDS81176.1
      UniProtKB/TrEMBL
      D3Z751
      Related
      ENSMUSP00000108728.2, ENSMUST00000113104.8
      Conserved Domains (1) summary
      cl11960
      Location:28124
      Ig; Immunoglobulin domain
    2. NM_177749.4NP_808417.2  killer cell immunoglobulin-like receptor 3DL1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_808417.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AY152727, AY530782
      Consensus CDS
      CCDS41134.1
      UniProtKB/Swiss-Prot
      P83555
      UniProtKB/TrEMBL
      Q673W3, Q673W4
      Related
      ENSMUSP00000108729.3, ENSMUST00000113105.3
      Conserved Domains (2) summary
      smart00410
      Location:3595
      IG_like; Immunoglobulin like
      cl11960
      Location:121217
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      135418748..135435055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)