U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Irs4 insulin receptor substrate 4 [ Mus musculus (house mouse) ]

    Gene ID: 16370, updated on 27-Nov-2024

    Summary

    Official Symbol
    Irs4provided by MGI
    Official Full Name
    insulin receptor substrate 4provided by MGI
    Primary source
    MGI:MGI:1338009
    See related
    Ensembl:ENSMUSG00000054667 AllianceGenome:MGI:1338009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IRS-4
    Summary
    Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; eye; and genitourinary system. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 9 and lung cancer. Orthologous to human IRS4 (insulin receptor substrate 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 1.0), testis adult (RPKM 0.8) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Irs4 in Genome Data Viewer
    Location:
    X F2; X 62.43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (140493994..140508213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (141710998..141725217, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 6 Neighboring gene STARR-seq mESC enhancer starr_48012 Neighboring gene prohibitin pseudogene Neighboring gene collagen, type IV, alpha 5 Neighboring gene STARR-seq mESC enhancer starr_48013 Neighboring gene predicted gene 15295 Neighboring gene STARR-seq mESC enhancer starr_48014 Neighboring gene STARR-seq mESC enhancer starr_48015 Neighboring gene high-mobility group nucleosomal binding domain 2-like 6 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol 3-kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    insulin receptor substrate 4
    Names
    phosphoprotein of 160 kDa
    pp160

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010572.2NP_034702.2  insulin receptor substrate 4

      See identical proteins and their annotated locations for NP_034702.2

      Status: VALIDATED

      Source sequence(s)
      AK045172, BC060235
      Consensus CDS
      CCDS30445.1
      UniProtKB/Swiss-Prot
      A2BHF6, Q8BRB9, Q9Z0Y7
      UniProtKB/TrEMBL
      B9EK93
      Related
      ENSMUSP00000067085.8, ENSMUST00000067841.8
      Conserved Domains (2) summary
      cd01204
      Location:232335
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:78203
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      140493994..140508213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)