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    Htr2a 5-hydroxytryptamine (serotonin) receptor 2A [ Mus musculus (house mouse) ]

    Gene ID: 15558, updated on 27-Nov-2024

    Summary

    Official Symbol
    Htr2aprovided by MGI
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 2Aprovided by MGI
    Primary source
    MGI:MGI:109521
    See related
    Ensembl:ENSMUSG00000034997 AllianceGenome:MGI:109521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htr2; Htr-2; 5-HT-2; 5-HT-2A; E030013E04
    Summary
    Enables protein tyrosine kinase activator activity. Acts upstream of or within positive regulation of fat cell differentiation; positive regulation of phosphate metabolic process; and protein localization to cytoskeleton. Predicted to be located in several cellular components, including cell body fiber; dendritic shaft; and neurofilament. Predicted to be part of G protein-coupled serotonin receptor complex. Predicted to be active in dendrite; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; embryo ectoderm; embryo mesenchyme; and heart. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; cocaine dependence; nicotine dependence; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.5), cortex adult (RPKM 2.6) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Htr2a in Genome Data Viewer
    Location:
    14 D3; 14 39.37 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (74878314..74944299)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (74640874..74706859)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L13a pseudogene Neighboring gene predicted gene, 41210 Neighboring gene STARR-positive B cell enhancer ABC_E5454 Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene esterase D/formylglutathione hydrolase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC124301, MGC124302

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables Gq/11-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Gq/11-coupled serotonin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serotonin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in artery smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in artery smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in detection of temperature stimulus involved in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of temperature stimulus involved in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating serotonin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytokine production involved in immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytokine production involved in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of execution phase of apoptosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of glycolytic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heat generation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of heat generation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of platelet aggregation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of dopamine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to xenobiotic stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensitization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sensitization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in temperature homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urinary bladder smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urinary bladder smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of G protein-coupled serotonin receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of G protein-coupled serotonin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neurofilament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neurofilament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 2A
    Names
    5-HT2A receptor
    5-hydroxytryptamine 2 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172812.3NP_766400.1  5-hydroxytryptamine receptor 2A

      Status: VALIDATED

      Source sequence(s)
      AK053140
      Consensus CDS
      CCDS27275.1
      UniProtKB/Swiss-Prot
      P35363
      UniProtKB/TrEMBL
      Q543D4
      Related
      ENSMUSP00000047774.4, ENSMUST00000036653.5
      Conserved Domains (2) summary
      pfam00001
      Location:91380
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:89207
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      74878314..74944299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)