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    Homer2 homer scaffolding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 26557, updated on 9-Dec-2024

    Summary

    Official Symbol
    Homer2provided by MGI
    Official Full Name
    homer scaffolding protein 2provided by MGI
    Primary source
    MGI:MGI:1347354
    See related
    Ensembl:ENSMUSG00000025813 AllianceGenome:MGI:1347354
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CPD; Vesl-2; 9330120H11Rik
    Summary
    Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within behavioral response to cocaine; calcium-mediated signaling; and regulation of G protein-coupled receptor signaling pathway. Located in apical part of cell; cytoplasm; and stereocilium tip. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; cranial nerve; jaw; sensory organ; and tongue. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 4.6) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Homer2 in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (81250229..81356673, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (81600481..81706925, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_19369 Neighboring gene STARR-positive B cell enhancer mm9_chr7:88715937-88716238 Neighboring gene WAS protein homolog associated with actin, golgi membranes and microtubules Neighboring gene microRNA 12203 Neighboring gene predicted gene, 32579 Neighboring gene predicted gene, 42400

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G protein-coupled glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables synaptic receptor adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular organelle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in stereocilium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homer protein homolog 2
    Names
    VASP/Ena-related gene up-regulated during seizure and LTP 2
    cupidin
    homer homolog 2
    homer, neuronal immediate early gene, 2
    homer-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164086.1NP_001157558.1  homer protein homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_001157558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC140366, AF093259, AK163423
      Consensus CDS
      CCDS85329.1
      UniProtKB/Swiss-Prot
      Q9QWW1
      Related
      ENSMUSP00000026922.9, ENSMUST00000026922.15
      Conserved Domains (2) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      TIGR02169
      Location:100315
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    2. NM_001164087.1NP_001157559.1  homer protein homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001157559.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140366, AF093260, CJ083069, DV657327
      Consensus CDS
      CCDS52284.1
      UniProtKB/TrEMBL
      E9Q4F9
      Related
      ENSMUSP00000095931.3, ENSMUST00000098326.3
      Conserved Domains (2) summary
      TIGR02168
      Location:103278
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:147
      PH-like; Pleckstrin homology-like domain
    3. NM_011983.2NP_036113.1  homer protein homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_036113.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC140366, AF093260, AK163423
      Consensus CDS
      CCDS40009.1
      UniProtKB/Swiss-Prot
      O89025, Q9QWW1, Q9Z0E4
      Related
      ENSMUSP00000146787.2, ENSMUST00000207983.2
      Conserved Domains (2) summary
      cd01206
      Location:3111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      TIGR02168
      Location:167342
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      81250229..81356673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540909.1XP_006540972.1  homer protein homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006540972.1

      UniProtKB/TrEMBL
      E9Q4F9
      Conserved Domains (2) summary
      TIGR02168
      Location:103278
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl17171
      Location:147
      PH-like; Pleckstrin homology-like domain
    2. XM_030242611.2XP_030098471.1  homer protein homolog 2 isoform X2

      Conserved Domains (2) summary
      TIGR02169
      Location:36251
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      cl17171
      Location:147
      PH-like; Pleckstrin homology-like domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177029.3: Suppressed sequence

      Description
      NM_177029.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.