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    Gstm1 glutathione S-transferase, mu 1 [ Mus musculus (house mouse) ]

    Gene ID: 14862, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gstm1provided by MGI
    Official Full Name
    glutathione S-transferase, mu 1provided by MGI
    Primary source
    MGI:MGI:95860
    See related
    Ensembl:ENSMUSG00000058135 AllianceGenome:MGI:95860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gstb1; Gstb-1
    Summary
    Enables identical protein binding activity. Acts upstream of or within cellular response to xenobiotic stimulus. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1) and GSTM5 (glutathione S-transferase mu 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 2975.4), liver adult (RPKM 1111.2) and 10 other tissues See more
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    Genomic context

    See Gstm1 in Genome Data Viewer
    Location:
    3 F2.3; 3 46.83 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (107919566..107925289, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108012250..108017973, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 12497 Neighboring gene glutathione S-transferase, mu 2 Neighboring gene STARR-seq mESC enhancer starr_08676 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:107820964-107821073 Neighboring gene predicted gene 12502 Neighboring gene predicted gene, 36498 Neighboring gene glutathione S-transferase, mu 4 Neighboring gene predicted gene, 25592

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nickel cation binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glutathione derivative biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepoxilin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in prostaglandin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase Mu 1
    Names
    GST 1-1
    GST class-mu 1
    glutathione S-transferase GT8.7
    pmGT10
    NP_001361607.1
    NP_034488.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374678.1NP_001361607.1  glutathione S-transferase Mu 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC079042, AL671877
      Consensus CDS
      CCDS89677.1
      UniProtKB/TrEMBL
      A2AE89
      Related
      ENSMUSP00000118874.3, ENSMUST00000126593.3
      Conserved Domains (2) summary
      cd03209
      Location:92238
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:384
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    2. NM_010358.5NP_034488.1  glutathione S-transferase Mu 1 isoform 2

      See identical proteins and their annotated locations for NP_034488.1

      Status: VALIDATED

      Source sequence(s)
      AI841190, AL671877, BC046758
      Consensus CDS
      CCDS17747.1
      UniProtKB/Swiss-Prot
      A2AE90, P10649, Q58ET5
      Related
      ENSMUSP00000004140.5, ENSMUST00000004140.11
      Conserved Domains (2) summary
      cd03209
      Location:92212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      cd03075
      Location:384
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      107919566..107925289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)