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    Aldh3a2 aldehyde dehydrogenase 3 family, member A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aldh3a2provided by RGD
    Official Full Name
    aldehyde dehydrogenase 3 family, member A2provided by RGD
    Primary source
    RGD:61866
    See related
    EnsemblRapid:ENSRNOG00000002342 AllianceGenome:RGD:61866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aldh4; FALDH
    Summary
    Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in formaldehyde metabolic process and response to reactive oxygen species. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1466.6), Lung (RPKM 194.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aldh3a2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46427789..46448449, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45928313..45949366, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47525486..47546535, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095325 Neighboring gene RAS related 2, pseudogene 1 Neighboring gene uncharacterized LOC120095114 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene solute carrier family 47 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, sequencing, and expression of cDNA for rat liver microsomal aldehyde dehydrogenase. Miyauchi K, et al. J Biol Chem, 1991 Oct 15. PMID 1717467
    2. A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Keller MA, et al. Nat Commun, 2014 Jul 22. PMID 25047030, Free PMC Article
    3. Characterisation of recombinant human fatty aldehyde dehydrogenase: implications for Sjögren-Larsson syndrome. Lloyd MD, et al. J Enzyme Inhib Med Chem, 2007 Oct. PMID 18035827
    4. Identification of fatty aldehyde dehydrogenase in the breakdown of phytol to phytanic acid. van den Brink DM, et al. Mol Genet Metab, 2004 May. PMID 15110319
    5. Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin. Demozay D, et al. J Biol Chem, 2004 Feb 20. PMID 14638678

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FALDH has roles in insulin action and is deregulated in states associated with altered insulin signaling
      Title: Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-chloroallyl aldehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain-alcohol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain-alcohol oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aldehyde metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermis development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formaldehyde metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hexadecanal metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexadecanal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hexadecanal metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peripheral nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peripheral nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phytol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phytol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sesquiterpenoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 3 member A2
    Names
    alcohol dehydrogenase family 3, subfamily A2
    aldehyde dehydrogenase 3A2
    aldehyde dehydrogenase 4
    aldehyde dehydrogenase family 3, subfamily A2
    fatty aldehyde dehydrogenase
    microsomal aldehyde dehydrogenase
    msALDH
    NP_113919.2
    XP_006246591.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031731.2 → NP_113919.2  aldehyde dehydrogenase family 3 member A2

      See identical proteins and their annotated locations for NP_113919.2

      Status: VALIDATED

      Source sequence(s)
      CB727458, CV109765, DW311997, EV780143, M73714
      UniProtKB/Swiss-Prot
      P30839
      UniProtKB/TrEMBL
      A6HF75
      Related
      ENSRNOP00000061762.2, ENSRNOT00000066109.5
      Conserved Domains (1) summary
      cd07132
      Location:5 → 444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46427789..46448449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246529.3 → XP_006246591.1  aldehyde dehydrogenase family 3 member A2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AF13, G3V9W6
      Related
      ENSRNOP00000091330.1, ENSRNOT00000103164.2
      Conserved Domains (1) summary
      cd07132
      Location:82 → 521
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30839.1 GenPept UniProtKB/Swiss-Prot:P30839

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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