Selenop selenoprotein P [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Selenopprovided by RGD
Official Full Name: selenoprotein Pprovided by RGD
Primary source: RGD:3660
See related: EnsemblRapid:ENSRNOG00000053086 AllianceGenome:RGD:3660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sepp1
Summary: This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in rat), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2017]
Expression: Biased expression in Liver (RPKM 24050.5), Kidney (RPKM 13784.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (54225736..54236022)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (52498123..52508409)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (53105912..53116198)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selenoprotein P promotes the development of pulmonary hypertension by stimulating excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells.
Title: Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: Possible Novel Therapeutic Target.
A chromatin immunoprecipitation (ChIP) assay revealed that EPA decreases binding of SREBP-1c to the SELENOP promoter. Knockdown of Srebf1 resulted in a significant down-regulation of Selenop expression.
Title: Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
Data indicate that Selenoprotein P SEPP1 processivity is intrinsic, but efficiency is governed by selenium levels.
Title: Regulation of selenocysteine incorporation into the selenium transport protein, selenoprotein P.
metformin decreases binding of FoxO3a, a direct target of AMPK, to the SEPP1 promoter.
Title: Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.
Sepp1 secreted from epithelial cells may support the intestinal immune system by providing immune cells (including plasma cells) with selenium
Title: Intestinal selenoprotein P in epithelial cells and in plasma cells.
apoER2-mediated uptake of long isoform Sepp1 is responsible for selenium distribution to tissues throughout the body.
Title: Long isoform mouse selenoprotein P (Sepp1) supplies rat myoblast L8 cells with selenium via endocytosis mediated by heparin binding properties and apolipoprotein E receptor-2 (ApoER2).
investigation of Sepp1 expression in adipocytes during adipogenesis and oxidative stress in models of obesity and insulin resistance
Title: Reducing selenoprotein P expression suppresses adipocyte differentiation as a result of increased preadipocyte inflammation.
tear SeP is a key molecule to protect the ocular surface cells against environmental oxidative stress
Title: Selenoprotein P controls oxidative stress in cornea.
High-level expression of SeP in liver is ensured by concerted action of the coactivator PGC-1alpha and the transcription factors FoxO1a and HNF-4alpha.
Title: Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors.
In conclusion, the selenoprotein P promoter is a target of the Akt/FoxO signal transduction cascade and SeP expression is regulated at the level of transcription by the forkhead box protein FoxO1a in human and rat hepatoma cells.
Title: Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables selenium binding	IBA Inferred from Biological aspect of Ancestor more info
enables selenium binding	IEA Inferred from Electronic Annotation more info
enables selenium binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in brain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	ISO Inferred from Sequence Orthology more info
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in selenium compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in selenium compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within selenium compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sexual reproduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: selenoprotein P

Names: seP; selenoprotein P, plasma, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083911.1 → NP_001077380.1 selenoprotein P precursor

See identical proteins and their annotated locations for NP_001077380.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as Sepp1b) uses an alternate 5' non-coding exon, hence has a different 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein containing 10 selenocysteine residues.

Source sequence(s)

BC072539, BF389559, CB699091, CB745388

UniProtKB/Swiss-Prot

P25236

Related

ENSRNOP00000069020.2, ENSRNOT00000086590.3

Conserved Domains (2) summary

pfam04592
Location:23 → 243

SelP_N; Selenoprotein P, N terminal region

pfam04593
Location:254 → 372

SelP_C; Selenoprotein P, C terminal region
NM_019192.2 → NP_062065.2 selenoprotein P precursor

See identical proteins and their annotated locations for NP_062065.2

Status: REVIEWED

Description

Transcript Variant: This variant (1, also known as Sepp1a) represents the predominant transcript. Variants 1 and 2 encode the same protein containing 10 selenocysteine residues.

Source sequence(s)

BC072539, BF389559, DN933732

UniProtKB/Swiss-Prot

P25236

Conserved Domains (2) summary

pfam04592
Location:23 → 243

SelP_N; Selenoprotein P, N terminal region

pfam04593
Location:254 → 372

SelP_C; Selenoprotein P, C terminal region