Eif4enif1 eukaryotic translation initiation factor 4E nuclear import factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif4enif1provided by MGI
Official Full Name: eukaryotic translation initiation factor 4E nuclear import factor 1provided by MGI
Primary source: MGI:MGI:1921453
See related: Ensembl:ENSMUSG00000020454 AllianceGenome:MGI:1921453
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clast4; D11Ertd166e; 2610509L04Rik; A930019J01Rik
Summary: Enables mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of translation; and stem cell population maintenance. Located in P-body; cytosol; and nucleus. Is expressed in several structures, including cerebral cortex; early conceptus; epithelium; metanephros; and ovary. Orthologous to human EIF4ENIF1 (eukaryotic translation initiation factor 4E nuclear import factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 18.2), CNS E11.5 (RPKM 15.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 2.24 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (3152344..3194588)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (3202343..3244588)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.
Title: Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Eif4enif1 (e-PCR), detects polymorphism
- UniSTS:507943

Eif4enif1 (e-PCR), detects polymorphism
- UniSTS:507944

AU021239 (e-PCR)
- UniSTS:160057

Eif4enif1 (e-PCR), detects polymorphism
- UniSTS:507966

D11Ertd166e (e-PCR), detects polymorphism
- UniSTS:167043

RH124916 (e-PCR)
- UniSTS:161738

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear export signal receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in P-body assembly	ISO Inferred from Sequence Orthology more info
involved_in P-body assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect miRNA-mediated gene silencing by inhibition of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear export	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of translation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in PML body	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E transporter

Names: 4E-T; CD40 ligand-activated specific transcript 4; eIF4E transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166547.1 → NP_001160019.1 eukaryotic translation initiation factor 4E transporter isoform a

See identical proteins and their annotated locations for NP_001160019.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

Source sequence(s)

AK165678, BC033410

Consensus CDS

CCDS24354.1

UniProtKB/Swiss-Prot

Q8CFW0, Q9CSS3, Q9EST3

UniProtKB/TrEMBL

Q8BY82

Related

ENSMUSP00000136768.2, ENSMUST00000179770.8

Conserved Domains (2) summary

pfam03154
Location:707 → 934

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 710

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
NM_001166548.1 → NP_001160020.1 eukaryotic translation initiation factor 4E transporter isoform b

See identical proteins and their annotated locations for NP_001160020.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AK041598, BC033410, CJ072393

Consensus CDS

CCDS48739.1

UniProtKB/TrEMBL

Q8BY82

Related

ENSMUSP00000020734.5, ENSMUST00000020734.11

Conserved Domains (2) summary

pfam03154
Location:683 → 910

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 686

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
NM_001166549.1 → NP_001160021.1 eukaryotic translation initiation factor 4E transporter isoform b

See identical proteins and their annotated locations for NP_001160021.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

BC033410, BY068596

Consensus CDS

CCDS48739.1

UniProtKB/TrEMBL

Q8BY82

Related

ENSMUSP00000105675.2, ENSMUST00000110048.8

Conserved Domains (2) summary

pfam03154
Location:683 → 910

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 686

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
NM_023743.2 → NP_076232.2 eukaryotic translation initiation factor 4E transporter isoform a

See identical proteins and their annotated locations for NP_076232.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode isoform a.

Source sequence(s)

AL671968, BC033410

Consensus CDS

CCDS24354.1

UniProtKB/Swiss-Prot

Q8CFW0, Q9CSS3, Q9EST3

UniProtKB/TrEMBL

Q8BY82

Related

ENSMUSP00000105676.2, ENSMUST00000110049.8

Conserved Domains (2) summary

pfam03154
Location:707 → 934

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 710

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

3152344..3194588

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514842.5 → XP_006514905.1 eukaryotic translation initiation factor 4E transporter isoform X1

See identical proteins and their annotated locations for XP_006514905.1

UniProtKB/Swiss-Prot

Q8CFW0, Q9CSS3, Q9EST3

UniProtKB/TrEMBL

Q8BY82

Conserved Domains (2) summary

pfam03154
Location:707 → 934

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 710

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
XM_006514844.4 → XP_006514907.1 eukaryotic translation initiation factor 4E transporter isoform X2

See identical proteins and their annotated locations for XP_006514907.1

UniProtKB/TrEMBL

Q8BY82

Conserved Domains (2) summary

pfam03154
Location:683 → 910

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 686

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
XM_006514841.4 → XP_006514904.1 eukaryotic translation initiation factor 4E transporter isoform X1

See identical proteins and their annotated locations for XP_006514904.1

UniProtKB/Swiss-Prot

Q8CFW0, Q9CSS3, Q9EST3

UniProtKB/TrEMBL

Q8BY82

Conserved Domains (2) summary

pfam03154
Location:707 → 934

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 710

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
XM_017314806.3 → XP_017170295.1 eukaryotic translation initiation factor 4E transporter isoform X2

UniProtKB/TrEMBL

Q8BY82

Conserved Domains (2) summary

pfam03154
Location:683 → 910

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 686

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
XM_006514843.5 → XP_006514906.1 eukaryotic translation initiation factor 4E transporter isoform X1

See identical proteins and their annotated locations for XP_006514906.1

UniProtKB/Swiss-Prot

Q8CFW0, Q9CSS3, Q9EST3

UniProtKB/TrEMBL

Q8BY82

Conserved Domains (2) summary

pfam03154
Location:707 → 934

Atrophin-1; Atrophin-1 family

pfam10477
Location:29 → 710

EIF4E-T; Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E