Tacr2 tachykinin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tacr2provided by RGD
Official Full Name: tachykinin receptor 2provided by RGD
Primary source: RGD:3812
See related: EnsemblRapid:ENSRNOG00000050658 AllianceGenome:RGD:3812
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tac2r
Summary: Enables substance K receptor activity. Involved in several processes, including operant conditioning; positive regulation of uterine smooth muscle contraction; and regulation of secretion by cell. Predicted to be located in sperm flagellum and sperm head. Predicted to be active in plasma membrane and sperm midpiece. Used to study colitis and pulmonary hypertension. Biomarker of colitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 43.0), Uterus (RPKM 5.5) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30751645..30766181)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30208907..30223446)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31892515..31905153)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress-induced increase in Tacr2 expression in the hypothalamus correlated with a specific decrease in DNA methylation of the Tacr2 gene.
Title: DNA methylation of the Tacr2 gene in a CUMS model of depression.
These results indicate that medial septal NK(2)-R have an important role in mediating acetylcholine release, for one, via the septal-hippocampal cholinergic projection and, secondly, via direct or indirect route to the amygdala, but not frontal cortex.
Title: Neurokinin2-R in medial septum regulate hippocampal and amygdalar ACh release induced by intraseptal application of neurokinins A and B.
Data show that injection of vehicle alone into the medial septum impaired memory for temporal order and spatial location, while the NK(2) receptor antagonist partially reversed this deficit by reinstating memory for temporal order.
Title: Neurokinin-2 receptor antagonism in medial septum influences temporal-order memory for objects and forebrain cholinergic activity.
Results suggest that the changes in tachykinin and receptor localization during colitis emphasize their role in both acute and repair phases.
Title: Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats.
activation of NK2 autoreceptors by NKs released from the peripheral afferent terminals or by mast cells during inflammatory responses may be a mechanism that sensitizes TRPV1 channels and enhances afferent excitability
Title: Neurokinin 2 receptor-mediated activation of protein kinase C modulates capsaicin responses in DRG neurons from adult rats.
Identification of a tachykinin NK(2) receptor splice variant.
Title: Identification of a tachykinin NK(2) receptor splice variant and its expression in human and rat tissues.
role for tachykinin NK-1 (and possibly for NK-2) receptors in tachykinin-mediated stimulation of vasopressin secretion from the rat hypothalamo hypophyseal system in vitro.
Title: Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists.
Data show that neurokinin-1 receptor (NK-1R) and neurokinin-2 receptor (NK-2R) contribute to intestinal damage, and are involved in pathophysiological changes in acute necrotizing pancreatitis
Title: Relationship between overexpression of NK-1R, NK-2R and intestinal mucosal damage in acute necrotizing pancreatitis.

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General gene information

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Markers

UniSTS:480303 (e-PCR)
- UniSTS:480303

Tacr2 (e-PCR), detects polymorphism
- UniSTS:480303

Tacr2 (e-PCR), detects polymorphism
- UniSTS:527573

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables substance K receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables substance K receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intestine smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of luteinizing hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in operant conditioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monoatomic ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of uterine smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prolactin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of uterine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in tachykinin receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm head	ISO Inferred from Sequence Orthology more info
is_active_in sperm midpiece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: substance-K receptor

Names: NK-2 receptor; NK-2R; SKR; Tachykinin 2 (substance K) receptor; neurokinin A receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080768.1 → NP_542946.1 substance-K receptor

See identical proteins and their annotated locations for NP_542946.1

Status: PROVISIONAL

Source sequence(s)

M31838

UniProtKB/Swiss-Prot

P16610

UniProtKB/TrEMBL

A6K431

Related

ENSRNOP00000067266.1, ENSRNOT00000071394.3

Conserved Domains (2) summary

pfam00001
Location:50 → 307

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:42 → 168

7tm_4; Olfactory receptor