Crcp calcitonin gene-related peptide-receptor component protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crcpprovided by MGI
Official Full Name: calcitonin gene-related peptide-receptor component proteinprovided by MGI
Primary source: MGI:MGI:1100818
See related: Ensembl:ENSMUSG00000025532 AllianceGenome:MGI:1100818
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables calcitonin gene-related peptide receptor activity. Acts upstream of or within neuropeptide signaling pathway. Located in acrosomal vesicle. Orthologous to human CRCP (CGRP receptor component). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 19.8), CNS E18 (RPKM 14.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.3; 5 68.42 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (130058147..130089628)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (130029306..130060787)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models.
Title: Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models.
CGRP can inhibit microglia activation in vivo in EAE. CGRP and its receptor may represent novel protective factors in EAE.
Title: Involvement of calcitonin gene-related peptide and receptor component protein in experimental autoimmune encephalomyelitis.
CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling.
Title: Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling.
The mouse cDNA for calcitonin receptor-like receptor (CRLR) was cloned. The signal transduction mechanism through the CGRP receptor was studied. mCRLR is a 462-amino acid G-protein-coupled heptahelical receptor.
Title: Molecular cloning and characterization of mouse calcitonin gene-related peptide receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-directed 5'-3' RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables DNA-directed 5'-3' RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcitonin gene-related peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase III promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of DNA polymerase III complex	ISO Inferred from Sequence Orthology more info
part_of DNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase III complex	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC9

Names: CGRP-RCP; CGRP-receptor component protein; CGRPRCP; RNA polymerase III subunit C9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.