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    Lrrc61 leucine rich repeat containing 61 [ Mus musculus (house mouse) ]

    Gene ID: 243371, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc61provided by MGI
    Official Full Name
    leucine rich repeat containing 61provided by MGI
    Primary source
    MGI:MGI:2652848
    See related
    Ensembl:ENSMUSG00000073096 AllianceGenome:MGI:2652848
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Orthologous to human LRRC61 (leucine rich repeat containing 61). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 24.9), testis adult (RPKM 17.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc61 in Genome Data Viewer
    Location:
    6 B2.3; 6 23.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48531732..48547656)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48554780..48570722)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit E2 Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene retinoic acid receptor responder (tazarotene induced) 2 Neighboring gene predicted gene 5111 Neighboring gene replication initiator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC28139

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110160.2 → NP_001103630.1  leucine-rich repeat-containing protein 61

      See identical proteins and their annotated locations for NP_001103630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 8 variants encode the same protein.
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS39478.1
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6
      Related
      ENSMUSP00000098979.3, ENSMUST00000101436.3
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:43 → 138
      internalin_A; class 1 internalin InlA

    2. NM_001411645.1 → NP_001398574.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC154013
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6

    3. NM_001411646.1 → NP_001398575.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC154013
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6

    4. NM_001411647.1 → NP_001398576.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC154013
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6

    5. NM_001411648.1 → NP_001398577.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC154013
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6

    6. NM_001411649.1 → NP_001398578.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC154013
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6

    7. NM_001411650.1 → NP_001398579.1  leucine-rich repeat-containing protein 61

      Status: VALIDATED

      Source sequence(s)
      AC154013
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6

    8. NM_177736.4 → NP_808404.2  leucine-rich repeat-containing protein 61

      See identical proteins and their annotated locations for NP_808404.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All 8 variants encode the same protein.
      Source sequence(s)
      AC154013
      Consensus CDS
      CCDS39478.1
      UniProtKB/Swiss-Prot
      Q3TB45, Q3UPT0, Q8R2R5
      UniProtKB/TrEMBL
      A0A0R4J1J6
      Related
      ENSMUSP00000110192.2, ENSMUST00000114545.8
      Conserved Domains (2) summary
      sd00033
      Location:55 → 76
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:43 → 138
      internalin_A; class 1 internalin InlA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48531732..48547656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2R5.1 GenPept UniProtKB/Swiss-Prot:Q8R2R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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